Synthesis of selenocysteine-containing cyclic peptides via tandem N-to-S acyl migration and intramolecular selenocysteine-mediated native chemical ligation
Synthesis of selenocysteine-containing cyclic peptides via tandem N-to-S acyl migration and intramolecular selenocysteine-mediated native chemical ligation
复制标题
通过串联 N-S 酰基迁移和分子内硒代半胱氨酸介导的天然化学连接合成含硒代半胱氨酸的环肽
DOI：
10.1039/c8cc06805d
复制
发表时间：
2018
影响因子：
4.9
通讯作者：
Iwaoka Michio
中科院分区：
文献类型：
--
作者：
Shimodaira Shingo;Takei Toshiki;Hojo Hironobu;Iwaoka Michio
通过N-烷基半胱氨酸（NAC）的酰基迁移和分子内硒代半胱氨酸介导的天然化学连接（Sec-NCL），一锅法成功合成了模拟谷胱甘肽过氧化物酶催化四联体的含硒半胱氨酸环状8肽。
Selenocysteine-containing cyclic 8-mer peptides, which were designed to mimic the plausible catalytic tetrad of glutathione peroxidase, were successfully synthesized in one pot via tandem N-to-S acyl migration of N-alkylcysteine (NAC)-containing selenopeptides and intramolecular selenocysteine-mediated native chemical ligation (Sec-NCL) of the generated thioesters.