RELATIONS AMONG ALVEOLAR SURFACE-TENSION, SURFACE-AREA, VOLUME, AND RECOIL PRESSURE
RELATIONS AMONG ALVEOLAR SURFACE-TENSION, SURFACE-AREA, VOLUME, AND RECOIL PRESSURE
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DOI：
10.1152/jappl.1987.62.5.1878
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发表时间：
1987-05-01
影响因子：
3.3
通讯作者：
WEIBEL, ER
中科院分区：
文献类型：
--
作者：
BACHOFEN, H;SCHURCH, S;WEIBEL, ER
对于肺结构-功能分析，通过血管灌注将切除的兔肺固定在压力-容积（P-V）曲线上的六个点，即在充气时为总肺容量（TLC）的40、80和100%，在放气时为80和40%TLC，以及在再充气时为80%TLC。固定前牙槽表面张力（γ）在整个P-V环的单个肺泡中测量，使用改进的微滴方法。最大γ关于. apprx在TLC下测量到30 mN/m，在肺放气期间，在40%TLC下降低至约1 mN/m。在从零压力开始的膨胀分支上的表面张力比在放气分支上的表面张力高得多（γ- V滞后）。相反，相应的肺泡表面积-体积（SA-V）的关系并没有形成一个完整的滞后在整个体积范围内。充气至40%TLC的肺之间SA有相当大的差异（1.49 ± 0.001）。0.11 m2）和肺放气至40%TLC（2.19 . ±. 0.21 m2），但在80%TLC下，SA值基本相同，与体积历史无关。数据表明，γ- SA滞后仅部分解释了P-V滞后，肺泡几何形状的决定因素随肺容积的变化而变化。在低肺容量时，空气空间尺寸似乎由表面力和组织力之间的相互作用决定。在较高的肺容量下，组织力成为主要的。
For pulmonary structure-function analysis excised rabbit lungs were fixed by vascular perfusion at six points on the pressure-volume (P-V) curve, i.e. at 40, 80, and 100% of total lung capacity (TLC) on inflation, at 80 and 40% TLC on deflation, and at 80% TLC on reinflation. Before fixation alveolar surface tensions (.gamma.) were measured in individual alveoli over the entire P-V loop, using an improved microdroplet method. A maximal .gamma. of .apprx. 30 mN/m was measured at TLC, which decreased during lung deflation to about 1 mN/m at 40% TLC. Surface tensions were considerably higher on the inflation limb starting from zero pressure than on the deflation limb (.gamma.-V hysteresis). In contrast, the corresponding alveolar surface area-volume (SA-V) relationship did not form a complete hysteresis over the entire volume range. There was a considerable difference in SA between lungs inflated to 40% TLC (1.49 .+-. 0.11 m2) and lungs deflated to 40% TLC (2.19 .+-. 0.21 m2), but at 80% TLC the values of SA were essentially the same regardless of the volume history. The data indicate that the .gamma.-SA hysteresis is only in part accountable for the P-V hysteresis and that the determinative factors of alveolar geometry change with lung volume. At low lung volumes airspace dimensions appear to be governed by an interplay between surface and tissue forces. At higher lung volumes the tissue forces become predominant.