Molecular Recognition-Mediated Transformation of Single-Chain Polymer Nanoparticles into Crosslinked Polymer Films
Molecular Recognition-Mediated Transformation of Single-Chain Polymer Nanoparticles into Crosslinked Polymer Films
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分子识别介导的单链聚合物纳米颗粒向交联聚合物薄膜的转化
DOI：
10.1002/ange.201706379
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发表时间：
2017
影响因子：
--
通讯作者：
Mahon C
中科院分区：
文献类型：
--
作者：
Mahon C
我们描述了具有分子内动态共价交联的单链聚合物纳米颗粒（SCNP），其可以通过分子识别介导的交联过程转化为聚合物膜。SCNP利用与表面固定化蛋白质的分子识别来集中在基底上，使SCNP在空间上彼此紧密接近，并允许其动态共价交联剂进行聚合物链内至互聚物链交联，从而形成聚合物膜。SCNP必须具有特定分子识别的能力和其分子内交联剂的动态性质以形成聚合物膜，并且对膜形成的初始阶段的调查表明它从在表面上形成的特征开始，然后主要在xy方向上生长。这种聚合物膜形成的方法提出了一种潜在的方法，“包裹”表面显示分子识别基序，这可能包括病毒，细胞和细菌表面或人工表面显示多价识别基序内的一层聚合物膜。
We describe single‐chain polymer nanoparticles (SCNPs) possessing intramolecular dynamic covalent crosslinks that can transform into polymer films through a molecular recognition‐mediated crosslinking process. The SCNPs utilise molecular recognition with surface‐immobilised proteins to concentrate upon a substrate, bringing the SCNPs into close spatial proximity with one another and allowing their dynamic covalent crosslinkers to undergo intra‐ to interpolymer chain crosslinking leading to the formation of polymeric film. SCNPs must possess both the capacity for specific molecular recognition and a dynamic nature to their intramolecular crosslinkers to form polymer films, and an investigation of the initial phase of film formation indicates it proceeds from features which form upon the surface then grow predominantly in the xy directions. This approach to polymer film formation presents a potential method to “wrap” surfaces displaying molecular recognition motifs—which could potentially include viral, cellular and bacterial surfaces or artificial surfaces displaying multivalent recognition motifs—within a layer of polymer film.