Decreased Filaggrin Level May Lead to Sweat Duct Obstruction in Filaggrin Mutant Mice.
Decreased Filaggrin Level May Lead to Sweat Duct Obstruction in Filaggrin Mutant Mice.
复制标题
丝聚蛋白水平降低可能导致丝聚蛋白突变小鼠的汗管阻塞。
DOI：
10.1016/j.jid.2016.07.036
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发表时间：
2017
影响因子：
6.5
通讯作者：
Kabashima K.
中科院分区：
文献类型：
--
作者：
Rerknimitr P;Tanizaki H;Yamamoto Y;Amano W;Nakajima S;Nakashima C;Nonomura Y;Wititsuwannakul J;Miyachi Y;Otsuka A;Kabashima K.
虽然汗水被认为是特应性皮炎(AD)的主要加重因素之一，但最近的研究表明，汗水对宿主防御和抗炎机制有好处(Murota等人，2015年，Watabe等人，2013年)。几项研究已经证明AD患者的出汗减少(Matsui等人，2014a，Matsui等人，2014b)，但确切的潜在机制尚不清楚。丝状蛋白(Flaggrin，Flg)是一种关键蛋白，参与皮肤屏障功能，已知AD患者的表皮中该蛋白减少(Otsuka等人，2014，Palmer等人，2006)。Flg有助于角质层(SC)的水合和皮肤的pH值。Flg在角质形成细胞的完整性中也起着重要作用，因为Flg水平的降低会引起SC的解体和角质形成细胞的异常分化(Brown和McLean，2012，Pendary等人，2014)。我们认为角质形成细胞中Flg表达的降低可能会影响角化过程中汗管的结构和功能，最终可能导致汗液分泌减少。
Although sweat is considered to be one of the major aggravating factors of atopic dermatitis (AD), recent studies have indicated the beneficial effects of sweat on host defense and antiinflammatory mechanisms (Murota et al., 2015, Watabe et al., 2013). Several studies have demonstrated that sweating is attenuated in patients with AD (Matsui et al., 2014a, Matsui et al., 2014b), but the precise underlying mechanisms remain unclear.Filaggrin (FLG) is a key protein involved in skin barrier function that is known to be decreased in the epidermis of patients with AD (Otsuka et al., 2014, Palmer et al., 2006). FLG contributes to stratum corneum (SC) hydration and skin pH. FLG also plays an important role in keratinocyte integrity, because a decreased FLG level gives rise to SC disintegration and abnormal keratinocyte differentiation (Brown and McLean, 2012, Pendaries et al., 2014). We consider that a decreased FLG expression in keratinocytes may affect the structure and function of sweat ducts that go through keratinization, which may eventually lead to a decrease of sweat secretion.