Rules relating connections to cortical structure in primate prefrontal cortex
Rules relating connections to cortical structure in primate prefrontal cortex
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DOI：
10.1016/s0925-2312(02)00356-9
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发表时间：
2002-06-01
期刊：
影响因子：
6
通讯作者：
Hilgetag, CC
中科院分区：
文献类型：
--
作者：
Barbas, H;Hilgetag, CC
根据前额叶皮质的结构模型，皮质皮质连接的模式与皮质架构错综复杂地联系在一起（Cereb. Cortex 7（1997）635）。我们进一步探讨了这个模型，用定量的方法来描述前额叶皮层的结构和连接。多参数分析区分不同的皮质类型，定位在一个极端内侧和眶额（边缘）皮质，并在另一个极端，外侧（eulaminate）皮质。结构模型准确地预测了连接的层状模式，以及皮质层内连接的相对分布，基于皮质类型。该模型可以提供基础来预测皮质处理的性质及其在精神和神经疾病中的破坏，其中神经病理学影响特定类型的神经元和层。(C)2002 Elsevier Science B.V.保留所有权利。
According to the structural model of prefrontal cortex, the pattern of corticocortical connections is intricately linked to cortical architecture (Cereb. Cortex 7 (1997) 635). We further explored this model by using quantitative methods to describe the structure and connections of prefrontal cortices. Multi-parameter analyses distinguished different cortical types, positioning at one extreme medial and orbitofrontal (limbic) cortices, and at the other extreme, lateral (eulaminate) cortices. The structural model accurately predicted the laminar pattern of connections, and the relative distribution of connections within cortical layers, based on cortical type. This model may provide the foundation to predict the nature of corticocortical processing and its disruption in psychiatric and neurologic diseases, where neuropathology affects specific types of neurons and layers. (C) 2002 Elsevier Science B.V. All rights reserved.