A comparison of multiple regimens of pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate vaccine and pneumococcal polysaccharide vaccine in toddlers
A comparison of multiple regimens of pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate vaccine and pneumococcal polysaccharide vaccine in toddlers
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DOI：
10.1016/s0264-410x(00)00021-9
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发表时间：
2000-05-08
期刊：
影响因子：
5.5
通讯作者：
McNeely, TB
中科院分区：
文献类型：
--
作者：
Blum, MD;Dagan, R;McNeely, TB
在12个月、15个月或IS个月时随机接种一剂七价肺炎球菌多糖-脑膜炎双球菌外膜蛋白复合体结合疫苗(PCV)或23价肺炎球菌多糖疫苗(PN23)的儿童随后被随机安排在12个月后接受PCV或PN23强化注射。对于那些在12、15或1个月大时注射PCV(N=75)而不是PN23(N=48)的儿童，在所有被测血清型的加强注射PCV或PN23后1个月获得了更高的血清抗体浓度(p<；0.001)。在接受PCV预充剂的儿童组中，那些接受增强剂量PN23的儿童在所测试的七种血清型中有四种的血清抗体浓度较高，与6B型血清抗体滴度相似，但注射部位的红斑(p=0.030)和疼痛(p=0.024)比增强PCV的儿童更常见。总而言之，在12-18个月龄时单次注射PCV为12个月后加强剂量的PCV或PN23的反应做好了准备。对于那些接受PCV初始剂量注射的儿童，注射PN23会导致比PCV注射更频繁的注射部位疼痛和红斑，但大多数被测试的血清型的抗体浓度更高。(C)2000爱思唯尔科学有限公司。保留所有权利。
Children who had been randomized to receive one dose of either heptavalent pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate vaccine (PCV) or 23-valent pneumococcal polysaccharide vaccine (PN23) at 12, 15, or Is months of age were subsequently randomized to receive a booster injection of either PCV or PN23 12 months later. For those children who received a priming dose of PCV (N = 75) compared to PN23 (N = 48) at 12, 15, or Is months of age, higher serum antibody concentrations were achieved 1 month following a booster injection of either PCV or PN23 for all serotypes tested (p < 0.001). Within the group of children receiving a priming dose of PCV, those children who received a booster dose of PN23 developed higher serum antibody concentrations for four of the seven serotypes tested and similar opsonic antibody titers to serotype 6B, yet more frequent erythema (p = 0.030) and pain or soreness (p = 0.024) at the injection site compared to those boosted with PCV. In conclusion, a single dose of PCV at 12-18 months of age primed for responses to booster doses of either PCV or PN23 12 months later. For those children who received a priming dose of PCV, boosting with PN23 resulted in more frequent injection site pain and erythema than boosting with PCV, yet higher antibody concentrations for most of the serotypes tested. (C) 2000 Elsevier Science Ltd. All rights reserved.