Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using 19F magnetic resonance imaging
Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using 19F magnetic resonance imaging
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DOI：
10.1016/j.neures.2008.10.006
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发表时间：
2009-01-01
影响因子：
2.9
通讯作者：
Tooyama, Ikuo
中科院分区：
文献类型：
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作者：
Amatsubo, Tomone;Morikawa, Shigehiro;Tooyama, Ikuo
通过非侵入性F-19磁共振成像(MRI)改进淀粉样蛋白检测的探针的化学性质令人感兴趣。我们合成了含三氟甲氧基的苯并恶唑类化合物，发现这些化合物在测定缓冲液中显示出尖锐的F-19核磁共振信号。然而，在小鼠脑裂解物中，F-19核磁共振信号的强度显著降低。我们的结果表明，脑组织对来自这些探针的F-19核磁共振信号的抑制作用可以归因于组织的疏水性。这些结果突显了使用亲水性F-19-MRI试剂以避免脑组织对F-19核磁共振信号的抑制作用的重要性。(C)2008年爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
The chemical properties of probes that improve amyloid detection by non-invasive F-19 magnetic resonance imaging (MRI)are of interest. We synthesized benzoxazole compounds with trifluoromethoxy groups, and found that these compounds displayed sharp F-19 nuclear magnetic resonance (NMR) signals in an assay buffer. However, the intensities of the F-19 NMR signals were dramatically reduced in mouse brain lysates. Our results indicate that the inhibitory effect of brain tissue on the F-19 NMR signals from these probes can be attributed to the hydrophobicity of the tissue. These results highlight the importance of using hydrophilic F-19-MRI agents to avoid the inhibitory effects of brain tissues on F-19 NMR signals. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.