Metal binding of Lissoclinum patella metabolites.: Part 1:: Patellamides A, C and ulithiacyclamide A
Metal binding of Lissoclinum patella metabolites.: Part 1:: Patellamides A, C and ulithiacyclamide A
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DOI：
10.1016/s0040-4020(01)00177-6
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发表时间：
2001-04-09
期刊：
影响因子：
2.1
通讯作者：
Price, NC
中科院分区：
文献类型：
--
作者：
Morris, LA;Jaspars, M;Price, NC
Studies on three Thz, and Oxn containing cyclic peptides, patellamide A and C (1, 3) and ulithiacyclamide A (9) isolated from the Indo-Pacific ascidian (seasquirt) Lissoclinum patella have delineated their metal binding selectivity. Patellamide C (3) shows extreme selectivity for Cu2+ even in the presence of an excess of Zn2+ and shows no binding at all to Co2+, Ni2+ and Hg2+. Patellamide A (1) is less selective for Cu2+, whereas ulithiacyclamide A (9) shows selectivity similar to that of patellamide C (3). The selectivity was studied by circular dichroism spectroscopy and mass spectrometry. The CD spectra obtained whilst patellamide C was slowly titrated with CU2+ show one isosbestic point indicating the CU2+ binding involves only two conformations. These studies indicate that CU2+, not Zn2+ is the biologically relevant metal for these compounds and point towards a potential ecological function of these complexes. (C) 2001 Elsevier Science Ltd. All rights reserved.
