The integration of depressive behaviors and cardiac dysfunction during an operational measure of depression: investigating the role of negative social experiences in an animal model.
The integration of depressive behaviors and cardiac dysfunction during an operational measure of depression: investigating the role of negative social experiences in an animal model.
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DOI：
10.1097/psy.0b013e31825ca8e5
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发表时间：
2012-07
影响因子：
3.3
通讯作者：
Preihs K
中科院分区：
文献类型：
--
作者：
Grippo AJ;Moffitt JA;Sgoifo A;Jepson AJ;Bates SL;Chandler DL;McNeal N;Preihs K
There is a bidirectional association between depression and cardiovascular disease. The neurobiological mechanisms underlying this association may involve an inability to cope with disrupted social bonds. This study investigated in an animal model the integration of depressive behaviors and cardiac dysfunction following a disrupted social bond and during an operational measure of depression, relative to the protective effects of intact social bonds. Depressive behaviors in the forced swim test and continuous electrocardiographic parameters were measured in 14 adult, female socially monogamous prairie voles (rodents), following 4 weeks of social pairing or isolation. Following social isolation, animals exhibited (all values are mean ± standard error of the mean, isolated vs. paired respectively) increased heart rate (416±14bpm vs. 370±14bpm, P<0.05) and reduced heart rate variability [3.3±0.2ln(ms2) vs. 3.9±0.2ln(ms2)]. During the forced swim test, isolated animals exhibited greater helpless behavior (immobility, 106±11sec vs. 63±11sec, P<0.05), increased heart rate (530±22bpm vs. 447±15bpm, P<0.05), reduced heart rate variability [1.8±0.4ln(ms2) vs. 2.7±0.2ln(ms2), P<0.05), and increased arrhythmias (arrhythmic burden score, 181±46 vs. 28±12, P<0.05). The display of depressive behaviors during an operational measure of depression is coupled with increased heart rate, reduced heart rate variability, and increased arrhythmias, indicative of dysfunctional behavioral and physiological stress-coping abilities as a function of social isolation. In contrast, social pairing with a sibling is behaviorally- and cardioprotective. The present results can provide insight into a possible social mechanism underlying the association of depression and cardiovascular disease in humans.
