GROWTH-ASSOCIATED PROTEIN, GAP-43, A POLYPEPTIDE THAT IS INDUCED WHEN NEURONS EXTEND AXONS, IS A COMPONENT OF GROWTH CONES AND CORRESPONDS TO PP46, A MAJOR POLYPEPTIDE OF A SUBCELLULAR FRACTION ENRICHED IN GROWTH CONES
GROWTH-ASSOCIATED PROTEIN, GAP-43, A POLYPEPTIDE THAT IS INDUCED WHEN NEURONS EXTEND AXONS, IS A COMPONENT OF GROWTH CONES AND CORRESPONDS TO PP46, A MAJOR POLYPEPTIDE OF A SUBCELLULAR FRACTION ENRICHED IN GROWTH CONES
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DOI：
10.1073/pnas.83.10.3537
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发表时间：
1986-05-01
影响因子：
11.1
通讯作者：
WILLARD, MB
中科院分区：
文献类型：
--
作者：
MEIRI, KF;PFENNINGER, KH;WILLARD, MB
生长相关蛋白GAP-43是神经元生长轴突时产生的一种多肽。我们通过亚细胞分离和免疫组织化学定位表明，GAP-43是神经元生长锥和生长神经突的组成部分；它类似于生长锥富集亚细胞部分的主要磷蛋白pp46。这些结论与诱导GAP-43/pp46在神经元能够延伸轴突的生产性生长状态的建立中是一个重要事件的可能性是一致的。
Growth-associated protein, GAP-43, is a polypeptide that is induced in neurons when they grow axons. We show by means of subcellular fractionation and immunohistochemical localization that GAP-43 is a component of neuronal growth cones as well as growing neurites; it is similar to a major phosphoprotein, pp46, of a growth cone-enriched subcellular fraction. These conclusions are consistent with the possibility that the induction of GAP-43/pp46 is an important event in the establishment of a productive growth state in which a neuron is competent to extend an axon.