Association of socioeconomic status with inflammation markers in black and white men and women in the Coronary Artery Risk Development in Young Adults (CARDIA) study
Association of socioeconomic status with inflammation markers in black and white men and women in the Coronary Artery Risk Development in Young Adults (CARDIA) study
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DOI：
10.1016/j.socscimed.2009.05.018
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发表时间：
2009-08-01
影响因子：
5.4
通讯作者：
Seeman, Teresa E.
中科院分区：
文献类型：
--
作者：
Gruenewald, Tara L.;Cohen, Sheldon;Seeman, Teresa E.
炎症过程与许多已知社会经济地位（SES）差异的疾病有关，包括心脏病和糖尿病。越来越多的证据还表明外周血炎症标志物水平存在 SES 梯度。然而，我们对 SES 与炎症之间潜在的性别和种族/民族差异知之甚少，尽管炎症相关疾病的负担因性别和种族而异。本研究调查了来自 CARDIA 研究的美国双族裔（白人和黑人）男性和女性样本（n = 3549，年龄 37-55 岁）中两种炎症生物标志物 C 反应蛋白 (CRP) 和白细胞介素 6 (IL-6) 水平的 SES（教育和收入）梯度。还检查了可能导致 SES 炎症生物标志物水平差异的健康状况、行为和社会心理变量。除黑人男性外，年龄调整后的 CRP 和 IL-6 水平与每个种族/性别组的教育水平呈负相关。在每个种族/性别组中还观察到 IL-6 的收入梯度以及 CRP 的白人女性和男性的收入梯度。一般来说，随着健康状况、行为和社会心理变量的加入，低 SES 组和高 SES 组之间 CRP 和 IL-6 水平的差异在幅度和显着性上都降低了，尽管添加模型协变量的影响因种族/性别组和不同 SES 炎症模型而异。总体而言，研究结果表明中年白人和黑人男性和女性炎症负担水平存在 SES 梯度。 (C) 2009 Elsevier Ltd. 保留所有权利。
Inflammatory processes are implicated in a number of diseases for which there are known socioeconomic status (SES) disparities, including heart disease and diabetes. Growing evidence also suggests SES gradients in levels of peripheral blood markers of inflammation. However, we know little about potential gender and racial/ethnic differences in associations between SES and inflammation, despite the fact that the burden of inflammation-related diseases varies by gender and race. The present study examines SES (education and income) gradients in levels of two inflammatory biomarkers, C-reactive protein (CRP) and interleukin-6 (IL-6), in a biethnic (White and Black) sample of men and women (n = 3549, aged 37-55 years) in the USA from the CARDIA Study. Health status, behavioral and psychosocial variables that may underlie SES differences in inflammatory biomarker levels were also examined. Age-adjusted CRP and IL-6 levels were inversely associated with education level in each race/gender group except Black males. income gradients were also observed in each race/gender group for IL-6 and in White females and males for CRP. In general, differences in CRP and IL-6 levels between low and high SES groups were reduced in magnitude and significance with the addition of health status, behavioral, and psychosocial variables, although the impact of the addition of model covariates varied across race/gender groups and different SES-inflammation models. Overall, findings indicate SES gradients in levels of inflammation burden in middle-aged White and Black males and females. (C) 2009 Elsevier Ltd. All rights reserved.