Functional Alteration of the DMN by Learned Regulation of the PCC Using Real-Time fMRI
Functional Alteration of the DMN by Learned Regulation of the PCC Using Real-Time fMRI
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DOI：
10.1109/tnsre.2012.2221480
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发表时间：
2013-07
影响因子：
4.9
通讯作者：
Gaoyan Zhang;Hang Zhang;Xiaoli Li;Xiao-jie Zhao;L. Yao;Zhi-ying Long
中科院分区：
文献类型：
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作者：
Gaoyan Zhang;Hang Zhang;Xiaoli Li;Xiao-jie Zhao;L. Yao;Zhi-ying Long
默认模式网络(DMN)是一个大脑区域的网络，这些区域在休息时活跃，在认知要求高的任务中受到抑制。此前的研究表明，DMN可以通过发育、衰老、紊乱、认知任务和离线训练来改变。然而，目前还不清楚DMN中的活动是否可以通过实时训练来改变。近年来，实时功能磁共振成像(RtfMRI)作为一种新的神经反馈技术被应用于训练受试者自愿控制特定脑区的活动。在目前的研究中，研究发现，通过使用rtfMRI来指导训练，受试者能够学习使用运动想象策略来减少后扣带皮质(PCC)的活动，这是DMN中的一个关键枢纽。实时训练后，静息状态DMN的内侧前额叶/扣带回(MPFC/ACC)活动降低。相比之下，没有神经反馈的对照组在训练后的安静状态下，DMN的MPFC/ACC活性增加。这些结果表明，这种rtfMRI技术具有很大的潜力用于DMN的调节，并可能成为研究大脑皮质功能可塑性的一种新方法。
The default mode network (DMN) is a network of brain regions that are active during rest and suppressed during a cognitively demanding task. Previous studies have shown that the DMN can be altered by development, aging, disorder, cognitive tasks and offline training. However, it's unclear whether activity in the DMN can be altered by real-time training. Recently, real-time functional magnetic resonance imaging (rtfMRI), as a novel neurofeedback technique, has been applied to train subjects to voluntarily control activities in specific brain regions. In the current study, it was found that by using rtfMRI to guide training, subjects were able to learn to decrease activity in the posterior cingulate cortex (PCC), which is a “key hub” in the DMN, using motor imagery strategy. After the real-time training, activity in the medial prefrontral cortex/ anterior cingulate cortex (MPFC/ACC) of the resting state DMN was decreased. By contrast, the control group without neurofeedback produced increased activity in the MPFC/ACC of the DMN during the post-training resting state. These findings suggest that this rtfMRI technique has great potential to be used in the regulation of the DMN and may be a novel approach for studying functional plasticity of the cortex.