Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology.
Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology.
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DOI：
10.3390/ijms13022219
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发表时间：
2012
影响因子：
5.6
通讯作者：
Pohanka M
中科院分区：
文献类型：
--
作者：
Pohanka M
α7烟碱型乙酰胆碱受体(α7nAChR)是大脑胆碱能神经系统的重要组成部分。此外，它还与终止副交感神经系统的胆碱能抗炎途径有关。α-7nAChR拮抗剂是以芋螺毒素和银环蛇毒素为代表的一大类拮抗剂。甚至阿尔茨海默病药物美金刚在其旁路中起拮抗剂的作用也属于这一组。α7nAChR激动剂适用于治疗阿尔茨海默病或精神分裂症等多种认知功能障碍。炎症甚至脓毒症可以通过激动型作用化合物来改善。制剂RG3487、SEN34625/WYE-103914、SEN12333、ABT-107、氯氮平、GTS-21、CNI-1493和AR-R17779是对α7nAChR具有亲和力的新化合物的代表性例子。本文对α-7nAChR的药理、毒理和药用意义进行了讨论。
Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of α7 nAChR are a wide group represented by conotoxin and bungarotoxin. Even Alzheimer’s disease drug memantine acting as an antagonist in its side pathway belongs in this group. Agonists of α7 nAChR are suitable for treatment of multiple cognitive dysfunctions such as Alzheimer’s disease or schizophrenia. Inflammation or even sepsis can be ameliorated by the agonistic acting compounds. Preparations RG3487, SEN34625/WYE-103914, SEN12333, ABT-107, Clozapine, GTS-21, CNI-1493, and AR-R17779 are representative examples of the novel compounds with affinity toward the α7 nAChR. Pharmacological, toxicological, and medicinal significance of α7 nAChR are discussed throughout this paper.
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影响因子：
24.5
作者：
Dotan, Iris;Rachmilewitz, Daniel;Hommes, Daniel
通讯作者：
Hommes, Daniel
影响因子：
4
作者：
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影响因子：
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作者：
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通讯作者：
de Alfonzo, RG
DOI：
10.1016/j.bbrc.2007.06.138
发表时间：
2007-09-14
影响因子：
3.1
作者：
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通讯作者：
Toth, Istvan
影响因子：
8.2
作者：
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通讯作者：
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