DEVELOPMENT OF PULMONARY VASCULAR-RESPONSE TO OXYGEN
DEVELOPMENT OF PULMONARY VASCULAR-RESPONSE TO OXYGEN
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DOI：
10.1152/ajpheart.1988.254.3.h542
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发表时间：
1988-03-01
影响因子：
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通讯作者：
LUNDGREN, CEG
中科院分区：
文献类型：
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作者：
MORIN, FC;EGAN, EA;LUNDGREN, CEG
从妊娠94天至146天，研究了胎羊肺循环对氧分压升高的反应能力。未麻醉的母羊在正常大气压下呼吸室内空气，然后在高压舱中在三个大气压绝对压力下呼吸100%氧气。在11只近足月羔羊（妊娠132 - 146天）中，胎儿动脉血氧分压（PaO 2）从25 +/- 1增加到55 +/- 6 Torr（平均值+/- SE），这使分配到胎儿肺的右心室输出比例从8 +/- 1增加到59 +/-5%。在5只极不成熟的羔羊（妊娠94 - 101天）中，胎儿PaO 2从27 +/- 1增加到174 +/- 70 Torr，但分配到肺的右心室输出量比例没有变化，为8 +/- 1至9 +/-1%。在5只近期羔羊中，测量肺血流量。它从34 +/- 3增加到298 +/- 35 ml.kg胎儿wt-1.min-1，增加了8.8倍。我们得出结论，胎羊的肺循环没有反应的增加，在妊娠前101天的氧分压，但是，在短期内增加的氧分压单独可以诱导整个增加肺血流量，通常发生在出生后的呼吸。
The ability of the pulmonary circulation of the fetal lamb to respond to a rise in oxygen tension was studied from 94 to 146 days of gestation. The unanesthetized ewe breathed room air at normal atmospheric pressure, followed by 100% oxygen at three atmospheres absolute pressure in a hyperbaric chamber. In eleven near-term lambs (132 to 146 days of gestation), fetal arterial oxygen tension (PaO2) increased from 25 +/- 1 to 55 +/- 6 Torr (mean +/- SE), which increased the proportion of right ventricular output distributed to the fetal lungs from 8 +/- 1 to 59 +/- 5%. In five very immature lambs (94 to 101 days of gestation), fetal PaO2 increased from 27 +/- 1 to 174 +/- 70 Torr, but the proportion of right ventricular output distributed to the lung did not change, 8 +/- 1 to 9 +/- 1%. In five of the near-term lambs, pulmonary blood flow was measured. It increased from 34 +/- 3 to 298 +/- 35 ml.kg fetal wt-1.min-1, an 8.8-fold increase. We conclude that the pulmonary circulation of the fetal lamb does not respond to an increase in oxygen tension before 101 days of gestation; however, near term an increase in oxygen tension alone can induce the entire increase in pulmonary blood flow that normally occurs after the onset of breathing at birth.