BOLD fMRI activation induced by vagus nerve stimulation in seizure patients
BOLD fMRI activation induced by vagus nerve stimulation in seizure patients
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DOI：
10.1136/jnnp.74.6.811
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发表时间：
2003-06-01
影响因子：
11
通讯作者：
Marks, D
中科院分区：
文献类型：
--
作者：
Liu, WC;Mosier, K;Marks, D
目的：为明确迷走神经刺激对癫痫患者脑内活动的影响，采用血氧水平依赖性功能磁共振成像（BOLD fMRI）技术，对5例复杂部分性癫痫患者迷走神经刺激激活的脑区进行研究。在每个患者进入扫描仪之前，迷走神经刺激器被设置为特定的开-关模式，使得可以使用箱式车类型的设计来分析数据。对大脑进行了解剖学和功能扫描。对功能图像进行头部运动校正，并与解剖图像配准。使用脑映射软件SPM 99生成并分析激活区域的地图。结果：所有患者均在额叶和枕叶出现激活。然而，激活丘脑中看到只有在两个病人改善癫痫control.Conclusions：BOLD功能磁共振成像可以检测激活与迷走神经刺激。丘脑激活和有利的临床结局之间可能存在关系。
Objective: To identify the cerebral activated regions associated with the vagus nerve stimulation in epilepsy patients.Design: Blood oxygenation level dependent functional magnetic resonance imaging ( BOLD fMRI) was employed to detect areas of the brain activated by vagus nerve stimulation in five patients with documented complex partial seizures.Methods: Functional MRI was done on a GE 1.5T Echospeed horizon scanner. Before each patient entered the scanner, the vagal nerve stimulator was set to a specific ON - OFF paradigm so that the data could be analysed using a box-car type of design. The brains were scanned both anatomically and functionally. The functional images were corrected for head motion and co-registered to the anatomical images. Maps of the activated areas were generated and analysed using the brain mapping software, SPM99. The threshold for activation was chosen as p < 0.001.Results: All patients showed activation in the frontal and occipital lobes. However, activation in the thalamus was seen only in the two patients with improved seizure control.Conclusions: BOLD fMRI can detect activation associated with vagus nerve stimulation. There may be a relation between thalamic activation and a favourable clinical outcome.