A Review of Delayed Delivery Models and the Analysis Method in Mice.
A Review of Delayed Delivery Models and the Analysis Method in Mice.
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DOI：
10.3390/jdb10020020
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发表时间：
2022-05-20
影响因子：
2.7
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中科院分区：
文献类型：
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在人类中，过期分娩的发生率为1- 10%。过期分娩显著增加剖宫产或新生儿重症监护病房（NICU）入院的风险。尽管存在这些严重挑战，但分娩时间延长的原因仍不清楚。小鼠和人类延迟分娩的几个共同因素将有助于阐明妊娠和分娩的机制。目前，基因修饰技术正在迅速发展，然而，有有限的评论描述小鼠表型分析作为人类模型的后期交付。我们将延迟分娩的小鼠按其原因分为九种类型。在小鼠中，孕酮（P）维持妊娠，延迟分娩的最常见原因是黄体溶解失败。其他影响因素包括胎儿/胎盘中的体液分子、子宫收缩功能障碍、宫颈成熟不良和着床延迟。延迟分娩的病因是妊娠维持机制的过度表达或引产机制的抑制。在这里，我们描述了如何使用小鼠遗传分析来调查其原因。此外，我们还生成了一个列表来确定原因。我们的综述将有助于理解使用小鼠模型获得的结果，为进行更系统的延迟分娩研究提供基础。
In humans, the incidence of post-term delivery is 1–10%. Post-term delivery significantly increases the risk of cesarean section or neonatal intensive care unit (NICU) admission. Despite these serious challenges, the cause of prolonged delivery remains unclear. Several common factors of delayed parturition between mice and humans will help elucidate the mechanisms of pregnancy and labor. At present, gene modification techniques are rapidly developing; however, there are limited reviews available describing the mouse phenotype analysis as a human model for post-term delivery. We classified the delayed-labor mice into nine types according to their causes. In mice, progesterone (P₄) maintains pregnancy, and the most common cause of delayed labor is luteolysis failure. Other contributing factors include humoral molecules in the fetus/placenta, uterine contractile dysfunction, poor cervical ripening, and delayed implantation. The etiology of delayed parturition is overexpression of the pregnancy maintenance mechanism or suppression of the labor induction mechanism. Here, we describe how to investigated their causes using mouse genetic analysis. In addition, we generated a list to identify the causes. Our review will help understand the findings obtained using the mouse model, providing a foundation for conducting more systematic research on delayed delivery.