UNTREATED BLOOD-PRESSURE LEVEL IS INVERSELY RELATED TO COGNITIVE-FUNCTIONING - THE FRAMINGHAM-STUDY
UNTREATED BLOOD-PRESSURE LEVEL IS INVERSELY RELATED TO COGNITIVE-FUNCTIONING - THE FRAMINGHAM-STUDY
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DOI：
10.1093/oxfordjournals.aje.a116868
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发表时间：
1993-09-15
影响因子：
5
通讯作者：
WHITE, LR
中科院分区：
文献类型：
--
作者：
ELIAS, MF;WOLF, PA;WHITE, LR
假设血压与认知功能呈负相关，如果不与抗高血压药物混淆，并在神经心理测试前多次测量。对于年龄在55-88岁的无中风的Framingham研究参与者（n = 1702），在1956-1964年间，当很少有高血压患者接受治疗时，他们的血压水平在5次两年一次的检查中平均下来，并在1976 - 1978年间进行了神经心理测试。在年龄、受教育程度、职业、吸烟、饮酒和性别控制的情况下，血压水平和高血压的慢性程度与综合得分以及注意力和记忆力的测量呈负相关。对于整个样本，在血压测量期间未经治疗的子样本（n = 1,485）以及在整个研究期间未经治疗的子样本（n = 1,038）都是如此。例如，血压每增加10mmhg，其下降范围为-0.04至-0.07标准评分单位(z)。先前的阴性结果很可能是由于血压测量与神经心理测试同时进行，或者测量太少。高血压相关的致病过程可能导致轻度认知障碍，但需要考虑其他机制。
It was hypothesized that blood pressure would be inversely related to cognitive functioning, if unconfounded with antihypertensive medication and measured over many occasions prior to neuropsychological testing. For stroke-free Framingham Study participants aged 55-88 years (n = 1,702), blood pressure levels were averaged over five biennial examinations (1956-1964) when few hypertensives were being treated, and examined in relation to neuropsychological tests administered between 1976 and 1978. With age, education, occupation, cigarette smoking, alcohol consumption, and gender controlled, blood pressure levels and chronicity of hypertension were inversely related to the composite score and measures of attention and memory. This was true for the full sample, for a subsample untreated during blood pressure measurement (n = 1,485), and for a subsample untreated throughout the entire study period (n = 1,038). For example, decline per 10 mmHg increment in blood pressure ranged from -0.04 to -0.07 standard score units (z) for the composite score. A negative finding previously was most likely due to blood pressure measurement concurrently with neuropsychological testing, or too few measurements. Hypertension-associated pathogenic processes may cause mild cognitive impairment, but other mechanisms need to be considered.