Striatal dopaminergic pathways as a target for the insecticides permethrin and chlorpyrifos
Striatal dopaminergic pathways as a target for the insecticides permethrin and chlorpyrifos
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DOI：
10.1016/s0161-813x(01)00063-8
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发表时间：
2001-12-01
期刊：
影响因子：
3.4
通讯作者：
Bloomquist, JR
中科院分区：
文献类型：
--
作者：
Karen, DJ;Li, W;Bloomquist, JR
由于接触杀虫剂与帕金森病和海湾战争疾病有关，因此在两周内用氯菊酯（腹膜内注射 3 剂，0.2-200 mg/kg）或毒死蜱（皮下注射 3 剂，25-100 mg/kg）的 C57BL/6 小鼠中研究了拟除虫菊酯和有机磷杀虫剂对行为和纹状体多巴胺能通路的神经毒性作用。期间。氯菊酯改变了治疗小鼠纹状体突触体的最大 [H-3] 多巴胺摄取，V-max 的变化呈现钟形曲线。剂量为 1.5 mg/kg 时，摄取量增加至对照的 134%。在较高剂量的 PM (25 mg/kg) 下，多巴胺摄取下降至显着低于对照的水平（200 mg/kg 时对照的 50%，P
Because insecticide exposure has been linked to both Parkinsons disease and Gulf War illness, the neurotoxic actions of pyrethroid and organophosphate insecticides on behavior and striatal dopaminergic pathways were investigated in C57BL/6 mice treated with permethrin (three i.p. doses at 0.2-200 mg/kg) or chlorpyrifos (three s.c. doses at 25-100 mg/kg) over a 2-week period. Permethrin altered maximal [H-3]dopamine uptake in striatal synaptosomes from treated mice, with changes in V-max displaying a bell-shaped curve. Uptake was increased to 134% of control at a dose of 1.5 mg/kg. At higher doses of PM (25 mg/kg), dopamine uptake declined to a level significantly below that of control (50% of control at 200 mg/kg, P