The basolateral amygdala is critical to the expression of pavlovian and instrumental outcome-specific reinforcer devaluation effects.
The basolateral amygdala is critical to the expression of pavlovian and instrumental outcome-specific reinforcer devaluation effects.
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DOI：
10.1523/jneurosci.3758-08.2009
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发表时间：
2009-01-21
期刊：
影响因子：
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通讯作者：
Holland PC
中科院分区：
文献类型：
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作者：
Johnson AW;Gallagher M;Holland PC
大量的证据表明，基底外侧杏仁核（BLA）在结果表征的形成，链接线索的激励属性的奖励。BLA损伤的动物表现出受损的表现在食物的贬值任务，其中的食物的价值是减少饱足或食物毒素配对完成后的线索或反应训练。虽然完整的动物自发地减少他们的条件反射后，这种训练减值程序，动物与BLA损伤前的训练通常不会，证明在一系列的物种，训练意外事件和减值程序。相比之下，一旦建立了这样的结果表示，BLA在贬值任务中的作用还不清楚。当在巴甫洛夫光→食物配对后但在食物-毒素配对贬值之前造成BLA损伤时，大鼠的贬值表现正常，当在多种工具反应和食物刺激的工具训练后但在选择性饱足贬值之前造成BLA损伤时，发现贬值表现受损。这些研究在使用巴甫洛夫或操作性训练突发事件，单个或多个事件，以及关联或动机贬值程序方面有所不同。在这里，我们发现，当使用多种抑制剂时，训练后BLA病变破坏了大鼠贬值性能的表达，使用巴甫洛夫或仪器训练程序，以及条件性味觉厌恶或饱足贬值程序。因此，BLA显然在维持或使用多个结果必须编码时，但不是在单一结果条件下的感觉关联的重复值中起着至关重要的作用。
Considerable evidence implicates the basolateral amygdala (BLA) in the formation of outcome representations that link cues to the incentive properties of reinforcers. Animals with BLA damage show impaired performance in reinforcer devaluation tasks, in which the value of the food reinforcer is reduced by satiation or food-toxin pairings after the completion of cue or response training. Although intact animals spontaneously reduce their conditioned responding after such reinforcer devaluation procedures, animals with BLA lesions made before training typically do not, as evidenced across a range of species, training contingencies and devaluation procedures. By contrast, the role of the BLA in devaluation task performance once such outcome representations are established is unclear. Whereas found normal devaluation performance in rats when BLA lesions were made after Pavlovian light→food pairings but before devaluation by food-toxin pairings, found impaired devaluation performance when BLA lesions were made after instrumental training with multiple instrumental responses and food reinforcers, but before devaluation of one reinforcer by selective satiation. Those studies differed in their use of Pavlovian or operant training contingencies, single or multiple reinforcers, and associative or motivational devaluation procedures. Here we found that when multiple reinforcers were used, post-training BLA lesions disrupted the expression of devaluation performance in rats, using either Pavlovian or instrumental training procedures, and either conditioned taste aversion or satiation devaluation procedures. Thus, BLA apparently plays a critical role in maintaining or using sensory associations of reinforcer value when multiple outcomes must be coded, but not under single-outcome conditions.