Immunological memory: lessons from the past and a look to the future
Immunological memory: lessons from the past and a look to the future
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DOI：
10.1038/nri.2016.13
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发表时间：
2016-02-01
影响因子：
100.3
通讯作者：
Zinkernagel, Rolf M.
中科院分区：
文献类型：
--
作者：
Farber, Donna L.;Netea, Mihai G.;Zinkernagel, Rolf M.
免疫记忆被认为是适应性免疫系统的主要特征之一。尽管自古希腊时代以来，免疫学家就已经认识到了这一现象，但他们还没有完全理解控制免疫系统记忆反应的机制。此外，我们对免疫记忆本身的定义也在不断发展，最近的研究表明，先天免疫细胞也表现出类似记忆的行为。在这篇观点文章中，自然评论免疫学邀请五位领先的免疫学家分享他们对我们目前对免疫记忆本质的理解的想法。我们的专家强调了一些塑造免疫记忆领域的开创性研究，并就仍有待解决的关键问题提出了相反的观点。
Immunological memory is considered to be one of the cardinal features of the adaptive immune system. Despite being a recognized phenomenon since the time of the ancient Greeks, immunologists are yet to fully appreciate the mechanisms that control memory responses in the immune system. Furthermore, our definition of immunological memory itself continues to evolve, with recent suggestions that innate immune cells also show memory-like behaviour. In this Viewpoint article, Nature Reviews Immunology invites five leading immunologists to share their thoughts on our current understanding of the nature of immunological memory. Our experts highlight some of the seminal studies that have shaped the immune memory field and offer contrasting views on the key questions that remain to be addressed.