Positive selection through a motif in the αβ T cell receptor
Positive selection through a motif in the αβ T cell receptor
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DOI：
10.1126/science.281.5378.835
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发表时间：
1998-08-07
期刊：
影响因子：
56.9
通讯作者：
Palmer, E
中科院分区：
文献类型：
--
作者：
Bäckström, BT;Müller, U;Palmer, E
T 细胞的两个谱系，αβ 和 γδ，其发育要求不同：只有 αβ 细胞需要主要组织相容性复合体识别，这一过程称为正选择。αβT 细胞受体 (TCR)，而不是其γδ 对应物，在 α 链连接肽结构域 (α-CPM) 中包含一个基序，该基序在过去 5 亿年中一直保守。在表达缺乏α-CPM的αβTCR的转基因小鼠中，胸腺细胞在正选择中被阻断，但可以经历负选择。因此，α-CPM 似乎参与了正选择所需信号的产生。
The two Lineages of T cells, alpha beta and gamma delta, differ in their developmental requirements: only alpha beta cells require major histocompatibility complex recognition, a process known as positive selection, The alpha beta T cell receptor (TCR), but not its gamma delta counterpart, contains a motif within the alpha-chain connecting peptide domain (alpha-CPM) that has been conserved over the Last 500 million years. In transgenic mice expressing an alpha beta TCR Lacking the alpha-CPM, thymocytes were blocked in positive selection but could undergo negative selection. Thus, the alpha-CPM seems to participate in the generation of signals required for positive selection.