PARAVENTRICULAR NUCLEUS - A SITE FOR THE INTEGRATION OF NEUROENDOCRINE AND AUTONOMIC MECHANISMS
PARAVENTRICULAR NUCLEUS - A SITE FOR THE INTEGRATION OF NEUROENDOCRINE AND AUTONOMIC MECHANISMS
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DOI：
10.1159/000123111
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发表时间：
1980-01-01
影响因子：
4.1
通讯作者：
SAWCHENKO, PE
中科院分区：
文献类型：
--
作者：
SWANSON, LW;SAWCHENKO, PE
我们在这里总结了最近的证据，阐明了大鼠下丘脑室旁核(PVH)的细胞结构和联系。细胞核由大细胞分裂和小细胞分裂组成，大细胞分裂有三个不同的部分，小细胞分裂有五个不同的部分。大细胞部的大多数神经元含有催产素或加压素，并投射到脑下垂体腺的后叶。以小细胞分裂为中心的独立细胞群可投射至正中隆起，或投射至脑干和脊髓，包括中间外侧柱；有些细胞既投射至迷走神经背侧复合体，又投射至脊髓。具有长下行投射的细胞可能含有催产素、加压素、生长抑素或多巴胺，尽管大多数此类神经元的生化特异性尚未确定。去甲肾上腺素能纤维主要分布在大细胞分裂中以加压素能为主的部分。小细胞分裂由来自脑干的肾上腺素能和去甲肾上腺素能纤维，以及来自迷走神经背侧复合体和臂旁核的纤维支配。终纹的床核和下丘脑的邻近部分也支配PVH。这些证据表明，PVH内的神经元亚群与自主神经和神经内分泌效应机制直接相关，并提示核团在调节外周和中枢神经系统的内脏反应中起着重要作用。
We have summarized here recent evidence that clarifies the cellular organization and connections of the paraventricular nucleus of the hypothalamus (PVH) in the rat. The nucleus consists of a magnocellular division, with three distinct parts, and a parvocellular division with five distinct parts. Most neurons in the magnocellular division contain either oxytocin or vasopressin, and project to the posterior lobe of the pituitary gland. Separate cell populations centered in the parvocellular division give rise to projections to the median eminence, or to the brain stem and spinal cord including the intermediolateral column; some cells project both to the dorsal vagal complex and to the spinal cord. Cells with long descending projections may contain either oxytocin, vasopressin, somatostatin, or dopamine, although the biochemical specificity of most such neurons has not been determined. Noradrenergic fibers are found preferentially within those parts of the magnocellular division that are predominantly vasopressinergic. The parvocellular division is innervated by adrenergic as well as noradrenergic fibers from the brain stem, and by fibers from the dorsal vagal complex and the parabrachial nucleus. The bed nucleus of the stria terminalis and adjacent parts of the hypothalamus also innervate the PVH. The evidence indicates that subpopulations of neurons in the PVH are directly related to autonomic and neuroendocrine effector mechanisms, and suggests that the nucleus plays an important role in the regulation of visceral responses in the periphery and in the CNS itself.