Is the conditioned pain modulation paradigm reliable? A test-retest assessment using the nociceptive withdrawal reflex.
Is the conditioned pain modulation paradigm reliable? A test-retest assessment using the nociceptive withdrawal reflex.
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DOI：
10.1371/journal.pone.0100241
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Curatolo M
中科院分区：
文献类型：
--
作者：
Biurrun Manresa JA;Fritsche R;Vuilleumier PH;Oehler C;Mørch CD;Arendt-Nielsen L;Andersen OK;Curatolo M
本研究的目的是以未来研究的假设样本量为分析目标，通过客观的电生理学方法、伤害性戒断反射(NWR)和心理物理测量来确定条件性疼痛调制(CPM)范式的可靠性。34名健康志愿者参加了两次相同的实验，间隔1到3周。采用冷加压试验(CPT)诱导大鼠CPM，并在CPT前和CPT中评价电刺激后的神经电刺激阈值、电痛觉阈值和疼痛强度分级。所有方法都一致地检测到CPM，电生理测量不会给评估带来额外的变化。特别是，99%的试验导致了CPT期间较高的NWR阈值，平均增加了3.4mA(p<；0.001)。同样，96%的试验在持续持续治疗期间导致更高的电痛检测阈值，平均增加2.2mA(p<；0.001)。在84%的试验中，阈值以上电刺激后的疼痛强度评级在持续治疗期间降低，在数字评级量表中显示平均下降1.5点(p<；0.001)。在这些实验条件下，就潜在实验的样本大小而言，CPM的可靠性对于所有评估方法都是可以接受的。关于CPM作为实验和临床疼痛评估工具的使用，目前的结果是令人鼓舞的。临床试验.gov NCT01636440
The aim of this study was to determine the reliability of the conditioned pain modulation (CPM) paradigm assessed by an objective electrophysiological method, the nociceptive withdrawal reflex (NWR), and psychophysical measures, using hypothetical sample sizes for future studies as analytical goals. Thirty-four healthy volunteers participated in two identical experimental sessions, separated by 1 to 3 weeks. In each session, the cold pressor test (CPT) was used to induce CPM, and the NWR thresholds, electrical pain detection thresholds and pain intensity ratings after suprathreshold electrical stimulation were assessed before and during CPT. CPM was consistently detected by all methods, and the electrophysiological measures did not introduce additional variation to the assessment. In particular, 99% of the trials resulted in higher NWR thresholds during CPT, with an average increase of 3.4 mA (p<0.001). Similarly, 96% of the trials resulted in higher electrical pain detection thresholds during CPT, with an average increase of 2.2 mA (p<0.001). Pain intensity ratings after suprathreshold electrical stimulation were reduced during CPT in 84% of the trials, displaying an average decrease of 1.5 points in a numeric rating scale (p<0.001). Under these experimental conditions, CPM reliability was acceptable for all assessment methods in terms of sample sizes for potential experiments. The presented results are encouraging with regards to the use of the CPM as an assessment tool in experimental and clinical pain. Clinical Trials.gov NCT01636440
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影响因子：
7.4
作者：
King CD;Wong F;Currie T;Mauderli AP;Fillingim RB;Riley JL 3rd
通讯作者：
Riley JL 3rd
DOI：
10.1097/ajp.0b013e3181bff800
发表时间：
2010-02
期刊：
The Clinical journal of pain
影响因子：
--
作者：
Heymen S;Maixner W;Whitehead WE;Klatzkin RR;Mechlin B;Light KC
通讯作者：
Light KC
影响因子：
9.8
作者：
Hopkins, WG
通讯作者：
Hopkins, WG
影响因子：
2
作者：
Julious, SA
通讯作者：
Julious, SA
影响因子：
14.5
作者：
Buchgreitz, L.;Egsgaard, L. L.;Bendtsen, L.
通讯作者：
Bendtsen, L.