CHROMOBLASTOMYCOSIS: A NEGLECTED TROPICAL DISEASE.
CHROMOBLASTOMYCOSIS: A NEGLECTED TROPICAL DISEASE.
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DOI：
10.1590/s0036-46652015000700009
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发表时间：
2015-09
影响因子：
1.9
通讯作者：
Queiroz-Telles F
中科院分区：
文献类型：
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作者：
Queiroz-Telles F
变色霉病(Chromoblastmycosis，CMB)是一种皮肤和皮下组织的慢性真菌感染，主要发生在世界各地的热带和亚热带地区。如果没有在早期得到诊断，CBM患者需要长期的全身抗真菌药物治疗，有时还需要物理方法。与其他被忽视的地方性真菌病不同，还没有对这种疾病进行对比临床试验。如今，治疗是基于一些公开试验和专家意见。伊曲康唑或作为单药治疗，或与其他药物联合使用，或与物理方法联合使用，被广泛使用。最近，光动力疗法已经成功地与抗真菌药物联合应用于表现为CBM的患者。在目前的修订中，综述了针对CBM最常用的治疗方案以及可能对患者预后产生影响的几个因素。
Chromoblastomycosis (CMB) is a chronic fungal infection of the skin and the subcutaneous tissue caused by a transcutaneous traumatic inoculation of a specific group of dematiaceous fungi occurring mainly in tropical and subtropical zones worldwide. If not diagnosed at early stages, patients with CBM require long term therapy with systemic antifungals, sometimes associated with physical methods. Unlike other neglected endemic mycoses, comparative clinical trials have not been performed for this disease. Nowadays, therapy is based on a few open trials and on expert opinion. Itraconazole either as monotherapy or associated with other drugs, or with physical methods, is widely used. Recently, photodynamic therapy has been successfully employed in combination with antifungals in patients presenting with CBM. In the present revision the most used therapeutic options against CBM are reviewed as well as the several factors that may have impact on the patient's outcome.