Reformatsky Reagent Promoted Acetylation of Primary and Secondary Aliphatic Alcohols Using Ethyl Acetate as an Acetyl Donor
Reformatsky Reagent Promoted Acetylation of Primary and Secondary Aliphatic Alcohols Using Ethyl Acetate as an Acetyl Donor
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Reformatsky 试剂使用乙酸乙酯作为乙酰基供体促进伯脂肪醇和仲脂肪醇的乙酰化
DOI：
10.1002/slct.201803162
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发表时间：
2019
期刊：
影响因子：
2.1
通讯作者：
Nakata Kenya
中科院分区：
文献类型：
--
作者：
Fujihara Rina;Nakata Kenya
研究发现，以Reformsky试剂为促进剂，以乙酸乙酯为溶剂和乙酰基供体的反应体系，在温和的条件下实现了多种伯仲醇的乙酰化反应。该反应可以通过简单的一锅操作进行，不需要加热。该反应表现出对各种官能团的高耐受性和化学选择性，使得酚羟基不发生反应。此外，该反应还可用于克级乙酰化反应。
The reaction system of a Reformatsky reagent as a promoter and EtOAc as a solvent and acetyl donor was found to achieve efficient acetylation of a variety of primary and secondary aliphatic alcohols under mild conditions. The reaction can be carried out by a simple one‐pot operation and does not require heating. The reaction shows a high tolerance for various functional groups and chemoselectivity, such that the phenolic hydroxyl groups do not react. Furthermore, the reaction can be used for gram‐scale acetylation.