Antimicrobial Resistance in Salmonella Strains Clinically Isolated in Hyogo, Japan (2009-2012)
Antimicrobial Resistance in Salmonella Strains Clinically Isolated in Hyogo, Japan (2009-2012)
复制标题
DOI：
10.7883/yoken.67.54
复制
发表时间：
2014-01-01
影响因子：
2.2
通讯作者：
Shirakawa, Toshiro
中科院分区：
文献类型：
--
作者：
Osawa, Kayo;Shigemura, Katsumi;Shirakawa, Toshiro
本研究的目的是检测195株沙门氏菌临床菌株的体外抗菌药物敏感性和遗传多样性，2009年至2012年在日本兵库分离并检查了超广谱β-内酰胺酶（ESBL）bla（CTX-M）基因以及gyrA、gyrB、parC和帕雷基因突变的存在。195株中有43株耐药。两种肠道沙门氏菌亚种经鉴定，肠球菌、Schwarzengrund血清型和肠杆菌血清型分别为bla（CTX-M-15）和bla（CTX-M-2）菌株。在8株耐萘啶酸的菌株中，有7株单独存在gyrA突变或gyrA和parC突变。总之，我们确定了CTX-M产ESBL沙门氏菌临床菌株的多重耐药。需要进一步的研究来监测日本这些严重的耐药沙门氏菌菌株。
The purpose of this study was to examine the in vitro susceptibilities to antimicrobial agents and genetic diversity of 195 clinical strains of Salmonella spp., which were isolated and examined for the extended-spectrum beta-lactamase (ESBL) bla(CTX-M) gene and the presence of gyrA, gyrB, parC, and parE genes mutations in Hyogo, Japan, from 2009 to 2012. Forty-three of the 195 strains were antimicrobial resistant. Two Salmonella enterica subsp. enterica strains, 1 serovar Schwarzengrund, and 1 serovar Enteritidis were identified as ESBL-producing strains possessing bla(CTX-M-15) and bla(CTX-M-2), respectively. Among 8 nalidixic acid-resistant strains, 7 had mutations in gyrA alone or in gyrA and parC. In conclusion, we identified CTX-M ESBL-producing Salmonella clinical strains with multidrug resistance. Further studies are needed to monitor these serious drug-resistant Salmonella strains in Japan.