Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights.
Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights.
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DOI：
10.21037/atm.2019.10.59
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发表时间：
2019-10
影响因子：
--
通讯作者：
V. Parcha;P. Arora
中科院分区：
文献类型：
--
作者：
V. Parcha;P. Arora
利钠肽（NPs）是心脏源性激素，其响应于增加的壁应力、心肌拉伸、容量超负荷和血管紧张素II刺激而分泌。主要的循环NP，心房和B型NP（分别为ANP和BNP）作为前体分子（proANP和proBNP）释放，前体分子被加工成活性组分ANP和BNP，以及非活性氨基末端片段NT-proANP和NT-proBNP（1）。
Natriuretic peptides (NPs) are cardiac derived hormones that are secreted in response to increased wall stress, stretching of the myocardium, volume overload, and angiotensin II stimulation. The principal circulating NPs, atrial and B-type NP (ANP and BNP respectively) are released as precursor molecules (proANP and proBNP) which are processed to active components ANP and BNP, and inactive amino-terminal fragments NT-proANP and NT-proBNP (1).