Double-negative T cells in autoimmune diseases.
Double-negative T cells in autoimmune diseases.
复制标题
自身免疫性疾病中的双阴性T细胞。
DOI：
10.1097/bor.0000000000000778
复制
发表时间：
2021-03-01
影响因子：
5.1
通讯作者：
Tsokos GC
中科院分区：
文献类型：
--
作者：
Li H;Tsokos GC
TCRα+ CD 4 − CD 8 −双阴性T（DNT）细胞是成熟T淋巴细胞的主要亚群，与自身免疫性/炎症性疾病密切相关。然而，关于它们的个体发育和功能仍然存在争议。在这里，我们提出了一个概述DN T细胞在不同的自身免疫性疾病，以推进更深入地了解这一人口的疾病发病机制的贡献。DNT细胞在各种慢性炎症性疾病中具有特征，并且它们被认为具有致病或调节功能。DN T细胞的组织定位和它们产生的效应细胞因子表明它们积极参与慢性炎症性疾病。通过产生各种细胞因子，发炎组织中扩增的DNT细胞有助于多种自身免疫性炎性疾病的发病机制。然而，目前尚不清楚该群体是否代表由类似于CD 4辅助性T细胞亚群的不同亚群组成的稳定谱系。需要更好地了解DNT细胞可能的异质性和可塑性，以揭示介入治疗的机会。
TCRα+CD4−CD8− double negative T (DNT) cells, a principal subset of mature T lymphocytes, have been closely linked with autoimmune/inflammatory conditions. However, controversy persists regarding their ontogeny and function. Here we present an overview on DN T cells in different autoimmune diseases to advance a deeper understanding of the contribution of this population to disease pathogenesis. DNT cells have been characterized in various chronic inflammatory diseases and they have been proposed to display pathogenic or regulatory function. The tissue location of DN T cells and the effector cytokines they produce bespeak to their active involvement in chronic inflammatory diseases. By producing various cytokines, expanded DNT cells in inflamed tissues contribute to the pathogenesis of a variety of autoimmune inflammatory diseases. However, it is unclear whether this population represents a stable lineage consisting of different subsets similar to CD4 T helper cell subset. Better understanding of the possible heterogeneity and plasticity of DNT cells is needed to reveal interventional therapeutic opportunities.