Alterations to the Cardiac Metabolome Induced by Chronic T. cruzi Infection Relate to the Degree of Cardiac Pathology.
Alterations to the Cardiac Metabolome Induced by Chronic T. cruzi Infection Relate to the Degree of Cardiac Pathology.
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DOI：
10.1021/acsinfecdis.0c00816
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发表时间：
2021-06-11
影响因子：
5.3
通讯作者：
McCall LI
中科院分区：
文献类型：
--
作者：
Hoffman K;Liu Z;Hossain E;Bottazzi ME;Hotez PJ;Jones KM;McCall LI
慢性查氏锥虫性心肌病（CCC）是由寄生虫克氏锥虫引起的一种被忽视的热带疾病。在有症状的CCC患者和动物模型中的特征性发现包括弥漫性心脏纤维化和炎症伴心脏中持续存在寄生虫。本研究调查了心脏不同区域的化学变化与心脏病理指标的关系，以更好地了解这种被忽视的疾病的长期发病机制。我们使用来自超声心动图、纤维化生物标志物和组织病理学分析的数据来全面评估心脏病理学。通过液相色谱串联质谱法分析从右心室心肌的心包和内膜侧分离的代谢产物。与心包切片相比，内膜切片包含的心脏炎症和纤维化显著较少。根据心脏纤维化、炎症和血清纤维化生物标志物水平，酰基肉毒碱、磷酸胆碱和其他代谢物的心脏水平被显著破坏。这些发现对CCC患者的治疗和监测具有潜在意义。
Chronic Chagasic cardiomyopathy (CCC) is a Neglected Tropical Disease caused by the parasite Trypanosoma cruzi. The pathognomonic findings in symptomatic CCC patients and animal models includes diffuse cardiac fibrosis and inflammation with persistent parasite presence in the heart. This study investigated chemical alterations in different regions of the heart in relation to cardiac pathology indicators to better understand the long-term pathogenesis of this neglected disease. We used data from echocardiography, fibrosis biomarkers, and histopathological analysis to fully evaluate cardiac pathology. Metabolites isolated from the pericardial and endocardial sides of the right ventricular myocardium were analyzed by liquid chromatography tandem mass spectrometry. The endocardial sections contained significantly less cardiac inflammation and fibrosis than the pericardial sections. Cardiac levels of acylcarnitines, phosphocholines, and other metabolites were significantly disrupted in accordance with cardiac fibrosis, inflammation, and serum fibrosis biomarker levels. These findings have potential implications in treatment and monitoring for CCC patients.
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影响因子：
3.8
作者：
Barreto-de-Albuquerque, Juliana;Silva-dos-Santos, Danielle;de Meis, Juliana
通讯作者：
de Meis, Juliana
影响因子：
3.8
作者：
de Oliveira FL;Araújo-Jorge TC;de Souza EM;de Oliveira GM;Degrave WM;Feige JJ;Bailly S;Waghabi MC
通讯作者：
Waghabi MC
影响因子：
7.1
作者：
Guasch-Ferre, Marta;Zhen, Yan;Salas-Salvado, Jordi
通讯作者：
Salas-Salvado, Jordi
影响因子：
3.1
作者：
Gomes, JAS;Bahia-Oliveira, LMG;Correa-Oliveira, R
通讯作者：
Correa-Oliveira, R
DOI：
10.1016/j.bbadis.2012.12.003
发表时间：
2013-03-01
影响因子：
6.2
作者：
Eric Ponce, Nicolas;Antonio Carrera-Silva, Eugenio;Pilar Aoki, Maria
通讯作者：
Pilar Aoki, Maria