Characteristics, risk factors and outcomes among the first consecutive 1096 patients diagnosed with COVID-19 in Kuwait
Characteristics, risk factors and outcomes among the first consecutive 1096 patients diagnosed with COVID-19 in Kuwait
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DOI：
10.1016/j.eclinm.2020.100448
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发表时间：
2020-07-01
影响因子：
15.1
通讯作者：
Al-Sabah, Salman
中科院分区：
文献类型：
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作者：
Almazeedi, Sulaiman;Al-Youha, Sarah;Al-Sabah, Salman
背景资料：在科威特，在该国报告首例COVID-19病例之前，对来自已知爆发疫情国家的入境旅客进行了大规模筛查，并导致该国首次发现病例。当时和之后的所有COVID-19病例都被转移到一个中心，Jaber Al-Ahmad Al-Sabah医院，在那里患者接受标准化的检查和治疗。本研究的目的是描述这一独特患者人群的人口统计学特征、临床表现和结局。方法：本回顾性队列研究于2020年2月24日至2020年4月20日进行。纳入了整个科威特国根据世卫组织指南诊断为COVID-19并在Jaber Al-Ahmad Al-Sabah医院住院的所有连续患者。患者接受标准化检查和治疗。多变量分析被用来确定危险因素和结果之间的关联（入院重症监护和/或死亡率）。结果：1096例患者，中位年龄为41岁，81%的患者为男性。大多数患者入院时无症状（46.3%），其中35人后来出现症状，59.7%无感染体征。在研究截止日期，只有3.6%的患者需要ICU入院，1.7%的患者死亡。在多变量分析中，发现与入住重症监护室显著相关的风险因素为年龄大于50岁、qSOFA评分大于0、吸烟、CRP升高和降钙素原水平升高。在我们的队列中，哮喘、吸烟和降钙素原水平升高与死亡率显著相关。(C)2020作者（S）爱思唯尔有限公司出版
Background: In Kuwait, prior to the first case of COVID-19 being reported in the country, mass screening of incoming travelers from countries with known outbreaks was performed and resulted in the first identified cases in the country. All COVID-19 cases at the time and subsequently after, were transferred to a single center, Jaber Al-Ahmad Al-Sabah Hospital, where the patients received standardized investigations and treatments. The objective of this study was to characterize the demographics, clinical manifestations, and outcomes in this unique patient population.Methods: This retrospective cohort study was conducted between 24th February 2020 and 20th April 2020. All consecutive patients in the entire State of Kuwait diagnosed with COVID-19 according to WHO guidelines and admitted to Jaber Al-Ahmad Al-Sabah Hospital were included. Patients received standardized investigations and treatments. Multivariable analysis was used to determine the associations between risk factors and outcomes (admission to intensive care and/or mortality).Findings: Of 1096 patients, the median age was 41 years and 81% of patients were male. Most patients were asymptomatic on admission (46.3%), of whom 35 later developed symptoms, and 59.7% had no signs of infection. Only 3.6% of patients required an ICU admission and 1.7% were dead at the study's cutoff date. On multivariable analysis, the risk factors found to be significantly associated with admission to intensive care were age above 50 years old, a qSOFA score above 0, smoking, elevated CRP and elevated procalcitonin levels. Asthma, smoking and elevated procalcitonin levels correlated significantly with mortality in our cohort. (C) 2020 The Author(s). Published by Elsevier Ltd.