A Triggered DNA Hydrogel Cover to Envelop and Release Single Cells
A Triggered DNA Hydrogel Cover to Envelop and Release Single Cells
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用于包裹和释放单细胞的触发式 DNA 水凝胶盖
DOI：
10.1002/adma.201301175
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发表时间：
2013-09-14
影响因子：
29.4
通讯作者：
Liu, Dongsheng
中科院分区：
文献类型：
--
作者：
Jin, Juan;Xing, Yongzheng;Liu, Dongsheng
我们开发了一种酶触发的可渗透DNA水凝胶盖，以包裹并释放微孔中的单细胞。DNA水凝胶的多孔结构允许营养物质和废物通过，导致细胞活力高达98%。该设计提供了一种培养、监测和操纵单细胞的通用方法，并在细胞图案化和研究细胞通讯方面具有潜在的应用。
We develop an enzyme-triggered permeable DNA hydrogel cover to envelop and release single cells in microwells. The porous structure of the DNA hydrogel allows nutrients and waste to pass through, leading to a cell viability as high as 98%. The design provides a general method to culture, monitor, and manipulate single cells, and has potential applications in cell patterning and studying cell communication.