Role of dopamine receptor subtypes in the acquisition of a testosterone conditioned place preference in rats
Role of dopamine receptor subtypes in the acquisition of a testosterone conditioned place preference in rats
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DOI：
10.1016/s0304-3940(00)00839-9
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发表时间：
2000-03
影响因子：
2.5
通讯作者：
J. Schroeder;M. Packard
中科院分区：
文献类型：
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作者：
J. Schroeder;M. Packard
本实验研究了睾酮奖赏特性的神经化学基础，着重于多巴胺能功能在睾酮条件性位置偏爱（CPP）获得中的作用。在两个实验中，成年雄性Long-Evans大鼠接受外周注射睾酮的水溶性羟丙基-β-环糊精包合物（0.8 mg/kg）或生理盐水，然后立即被限制在位置偏爱装置的两个隔室之一30分钟。在第10天，给予大鼠20分钟的测试期，并允许进入装置的所有隔室。在测试之前不注射激素，并且记录在装置的每个隔室中花费的时间量。在每个实验中，发现睾酮的施用诱导CPP。注射混合D1/D2受体拮抗剂α-氟哌噻吨（0.3 mg/kg）、选择性D1受体拮抗剂SCH 23390（0.1 mg/kg）或选择性D2受体拮抗剂舒必利（20 mg/kg）均阻断睾酮CPP的获得。研究结果表明，多巴胺D1和D2受体亚型在获得睾酮CPP中的作用。
The present experiments investigated the neurochemical bases of the rewarding properties of testosterone, focusing on the role of dopaminergic function in the acquisition of a testosterone conditioned place preference (CPP). In two experiments for 8 alternating days adult male Long–Evans rats received peripheral injections of testosterone in a water-soluble hydroxypropyl-β-cyclodextrin inclusion complex (0.8 mg/kg) or saline immediately prior to being confined for 30 min to one of two compartments of a place preference apparatus. On day 10 the rats were given a 20-min test session and allowed access to all compartments of the apparatus. No hormone was injected prior to the test, and the amount of time spent in each compartment of the apparatus was recorded. In each experiment administration of testosterone was found to induce a CPP. Injections of the mixed D1/D2 receptor antagonist α-flupenthixol (0.3 mg/kg), the selective D1 antagonist SCH 23390 (0.1 mg/kg), or the selective D2 antagonist sulpiride (20 mg/kg), each blocked acquisition of the testosterone CPP. The findings suggest a role for both dopamine D1 and D2 receptor subtypes in the acquisition of testosterone CPP.