New insights into spontaneous intestinal perforation using a national data set (3): antenatal steroids have no adverse association with spontaneous intestinal perforation
New insights into spontaneous intestinal perforation using a national data set (3): antenatal steroids have no adverse association with spontaneous intestinal perforation
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DOI：
10.1038/sj.jp.7211589
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发表时间：
2006-11-01
影响因子：
2.9
通讯作者：
Gordon, P. V.
中科院分区：
文献类型：
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作者：
Attridge, J. T.;Clark, R.;Gordon, P. V.
目标：研究产前类固醇（ANS）单独使用或与早期吲哚美辛联合使用是否与自发性肠穿孔（SIP）相关。SIP是一个已知的并发症并发症，同时出生后给予糖皮质激素和吲哚美辛在极低出生体重（ELBW）infants.Study design：一个大型的去识别的国家数据集进行了回顾性研究，SIP的婴儿没有任何其他畸形或坏死性肠炎的报告。然后根据性别和出生体重（+/- 20 g）得出对照组。产前和产后的变量进行了测试，单变量和多变量分析，以确定与SIP.Results协会：从1996年1月至2004年6月，有2 27 711出院的Pediatrix新生儿重症监护病房网站。从这一人群中，388名患有与ELBW相关的SIP的婴儿与匹配的对照组进行了比较。患有SIP的婴儿更有可能在早期接受吲哚美辛治疗，并在早期接受吲哚美辛与出生后糖皮质激素联合治疗（P
Objective: To examine whether antenatal steroids (ANS), alone or with early indomethacin, are associated with spontaneous intestinal perforation (SIP). SIP is a known complication of concurrent post-natal administration of glucocorticoid and indomethacin in extremely low birth weight (ELBW) infants.Study design: A large de-identified national data set was retrospectively examined for infants with SIP without any report of other malformation or necrotizing entrocolitis. A control group was then derived matching for gender and birth weight (+/- 20 g). Pre- and post-natal variables were tested by both univariate and multivariate analysis to identify associations with SIP.Results: From January 1996 to June 2004, there were 2 27 711 discharges from Pediatrix neonatal intensive care unit sites. From this population 388 infants with SIP associated with ELBW were compared to matched controls. Infants with SIP were more likely to have received early indomethacin and to have received a combination of early indomethacin with post-natal glucocorticoids (P