Aberrant Functional Whole-Brain Network Architecture in Patients With Schizophrenia: A Meta-analysis
Aberrant Functional Whole-Brain Network Architecture in Patients With Schizophrenia: A Meta-analysis
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DOI：
10.1093/schbul/sbv174
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发表时间：
2016-07-01
影响因子：
6.6
通讯作者：
Malchow, Berend
中科院分区：
文献类型：
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作者：
Kambeitz, Joseph;Kambeitz-Ilankovic, Lana;Malchow, Berend
多项研究的结果提供了精神分裂症患者大脑功能连接异常的证据。通过使用图形分析方法，最近的研究表明，精神分裂症患者的全脑网络组织原理发生了变化，并且这些变化与认知症状有关。然而，尚未对精神分裂症的功能性大脑网络变化进行系统调查，以测试多项研究中这些变化的一致性。我们进行了全面的文献检索，以确定所有可用的精神分裂症患者的功能图分析研究。效应大小测量值来自每项研究，并输入随机效应荟萃分析模型。所有模型都测试了潜在调节变量的影响以及发表偏倚的存在。总共 n = 13 项功能神经影像研究的结果表明，精神分裂症患者的大脑网络表现出局部组织测量显着下降（g = -0.56，P = .02）和小世界显着下降（g = -0.65，P = .01），而全局短通信路径似乎保留下来（g = 0.26，P = .32）。没有证据表明存在出版偏见或调节效应。目前的荟萃分析表明，各项研究中与精神分裂症相关的全脑网络结构发生了显着变化。
Findings from multiple lines of research provide evidence of aberrant functional brain connectivity in schizophrenia. By using graph-analytical measures, recent studies indicate that patients with schizophrenia exhibit changes in the organizational principles of whole-brain networks and that these changes relate to cognitive symptoms. However, there has not been a systematic investigation of functional brain network changes in schizophrenia to test the consistency of these changes across multiple studies. A comprehensive literature search was conducted to identify all available functional graph-analytical studies in patients with schizophrenia. Effect size measures were derived from each study and entered in a random-effects meta-analytical model. All models were tested for effects of potential moderator variables as well as for the presence of publication bias. The results of a total of n = 13 functional neuroimaging studies indicated that brain networks in patients with schizophrenia exhibit significant decreases in measures of local organization (g = -0.56, P = .02) and significant decreases in small-worldness (g = -0.65, P = .01) whereas global short communication paths seemed to be preserved (g = 0.26, P = .32). There was no evidence for a publication bias or moderator effects. The present meta-analysis demonstrates significant changes in whole brain network architecture associated with schizophrenia across studies.