XETOR regulates the size of the proneural domain during primary neurogenesis in Xenopus laevis
XETOR regulates the size of the proneural domain during primary neurogenesis in Xenopus laevis
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DOI：
10.1016/s0925-4773(02)00285-x
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发表时间：
2002-11-01
影响因子：
2.6
通讯作者：
Grunz, H
中科院分区：
文献类型：
--
作者：
Cao, Y;Zhao, H;Grunz, H
早期原神经基因和侧抑制之间的相互作用决定了初级神经元的数量。然而，调节原神经域大小的机制尚未阐明。我们在此表明，抑制非洲爪蟾中 XETOR（人类癌蛋白 ETO/MTG8 的同源物）的功能，会导致原神经结构域扩大的神经源性表型，而不改变原代神经元的密度。这一结果表明 XETOR 是调节原神经域大小的先决条件。我们进一步表明，这种调节是通过在 XETOR 和除 Xngnr-1 之外的原神经基因之间建立负反馈环，以及通过 XETOR 和侧抑制之间的拮抗作用来完成的。 (C) 2002 Elsevier Science Ireland Ltd. 保留所有权利。
The interaction between early proneural genes and lateral inhibition determines the number of primary neurons. The mechanism for regulating the size of the proneural domain, however, has not been clarified. We show here that inhibition of the function of XETOR in Xenopus, a homolog of human oncoprotein ETO/MTG8, leads to a neurogenic phenotype of expanded proneural domain without alteration in the density of primary neurons. This result suggests that XETOR is a prerequisite for regulating the size of the proneural domain. We further show that such a regulation is accomplished by establishing a, negative feedback loop between XETOR and proneural genes except Xngnr-1, as well as by antagonism between XETOR and lateral inhibition. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.