Adult weight change, weight cycling, and prepregnancy obesity in relation to risk of preeclampsia
Adult weight change, weight cycling, and prepregnancy obesity in relation to risk of preeclampsia
复制标题
DOI：
10.1097/01.ede.0000221028.33245.0b
复制
发表时间：
2006-07-01
期刊：
影响因子：
5.4
通讯作者：
Williams, Michelle A.
中科院分区：
文献类型：
--
作者：
Frederick, Ihunnaya O.;Rudra, Carole B.;Williams, Michelle A.
背景资料：先兆子痫已被证明与肥胖，与其他心血管疾病的危险因素，并与随后的心血管疾病本身然而，可能与体重增加和体重循环尚未evaluated.Methods：在这一前瞻性研究的队列1644名孕妇，我们评估了成人体重变化，故意体重循环，和孕前肥胖症先兆子痫的风险。从18岁到怀孕前3个月期间的净体重变化被确定为每个参与者。体重循环定义为在与妊娠或哺乳无关的时期内，故意减轻体重，无意中体重恢复至少15磅。结果：相对于体重稳定（增加或减少< 2.5 kg）的妇女，体重增加5.0-9.9 kg的妇女发生先兆子痫的风险增加2.6倍（95%CI = 1.0-6.7）。体重增加>= 10 kg的女性的相应风险比（RR）为5.1（2.2-12.2）。在控制了18岁时的体重、成人体重变化和其他危险因素后，有意的体重循环与先兆子痫风险增加无关（RR = 1.1; CI = 0.6-1.8）。随着孕前体重指数大于19.8 kg/m2，RR单调增加。校正混杂因素后，孕前超重妇女和肥胖妇女的RR分别为1.7（0.6-4.9）和3.4（1.5- 7.6.Conclusions）：这些结果表明，成年体重增加和孕前超重和肥胖状态与先兆子痫的风险增加。
Background: Preeclampsia has been shown to be associated with obesity, with other risk factors for cardiovascular disease, and with subsequent cardiovascular disease itself However, the possible association with weight gain and weight cycling has not been evaluated.Methods: In this prospective study of a cohort of 1644 pregnant women, we assessed adult weight change, intentional weight cycling, and prepregnancy obesity in relation to preeclampsia risk. Net weight change from age 18 years to the period 3 months before conception was determined for each participant. Weight cycling was defined as intentional weight loss and unintentional regain of at least 15 pounds during periods not related to pregnancy or lactation. We used multivariate regression procedures to calculate risk ratios (RRs) and 95% confidence intervals (CIs).Results: Relative to women with stable weight (gained or lost < 2.5 kg) women who gained 5.0-9.9 kg experienced a 2.6-fold increased risk of preeclampsia (95% CI = 1.0-6.7). The corresponding risk ratio (RR) for women who gained >= 10 kg was 5.1 (2.2-12.2). Intentional weight cycling, after controlling for weight at age 18 years, adult weight change, and other risk factors, was not associated with increased risk of preeclampsia (RR = 1.1; CI = 0.6-1.8). RRs increased monotonically with increasing prepregnancy body mass index greater than 19.8 kg/m(2). After adjusting for confounders, the RR for prepregnancy overweight women and obese women were 1.7 (0.6-4.9) and 3.4 (1.5-7.6) respectively.Conclusions: These results suggest that adult weight gain and prepregnancy overweight and obesity status are associated with an increased risk of preeclampsia.