Randomized Controlled Trial of Hospital-Based Hygiene and Water Treatment Intervention (CHoBI7) to Reduce Cholera.
Randomized Controlled Trial of Hospital-Based Hygiene and Water Treatment Intervention (CHoBI7) to Reduce Cholera.
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DOI：
10.3201/eid2202.151175
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发表时间：
2016-02
影响因子：
11.8
通讯作者：
Alam M
中科院分区：
文献类型：
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作者：
George CM;Monira S;Sack DA;Rashid MU;Saif-Ur-Rahman KM;Mahmud T;Rahman Z;Mustafiz M;Bhuyian SI;Winch PJ;Leontsini E;Perin J;Begum F;Zohura F;Biswas S;Parvin T;Zhang X;Jung D;Sack RB;Alam M
这种干预措施显著减少了症状性霍乱弧菌感染。在霍乱患者寻求医院护理后的一周内，与霍乱患者有家庭接触的人感染霍乱的风险比一般人群高100倍以上。为了启动对这一高危人群的标准护理，我们开发了霍乱医院干预7天（CHoBI 7），促进用肥皂洗手和水处理。为了测试CHoBI 7，我们在2013-2014年期间在孟加拉国达卡的82名霍乱患者的219名干预家庭接触者和83名霍乱患者的220名对照接触者中进行了一项随机对照试验。干预接触者的症状性霍乱弧菌感染明显少于对照接触者，总体霍乱弧菌感染减少47%。在监测第5、6或7天的结构化观察期间，干预家庭没有储存含霍乱弧菌的饮用水，在关键事件中用肥皂洗手的几率高出14倍。CHoBI 7为在霍乱患者的高度易感家庭接触者中控制霍乱提供了一种有希望的方法。
This intervention significantly reduced symptomatic Vibrio cholerae infection. The risk for cholera infection is >100 times higher for household contacts of cholera patients during the week after the index patient seeks hospital care than it is for the general population. To initiate a standard of care for this high-risk population, we developed Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7), which promotes hand washing with soap and treatment of water. To test CHoBI7, we conducted a randomized controlled trial among 219 intervention household contacts of 82 cholera patients and 220 control contacts of 83 cholera patients in Dhaka, Bangladesh, during 2013–2014. Intervention contacts had significantly fewer symptomatic Vibrio cholerae infections than did control contacts and 47% fewer overall V. cholerae infections. Intervention households had no stored drinking water with V. cholerae and 14 times higher odds of hand washing with soap at key events during structured observation on surveillance days 5, 6, or 7. CHoBI7 presents a promising approach for controlling cholera among highly susceptible household contacts of cholera patients.