Changing epidemiology of neovascular glaucoma from 2002 to 2012 at King Khaled Eye Specialist Hospital, Saudi Arabia.
Changing epidemiology of neovascular glaucoma from 2002 to 2012 at King Khaled Eye Specialist Hospital, Saudi Arabia.
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DOI：
10.4103/ijo.ijo_33_17
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发表时间：
2017-10
影响因子：
3.1
通讯作者：
Kozak I
中科院分区：
文献类型：
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作者：
Al-Bahlal A;Khandekar R;Al Rubaie K;Alzahim T;Edward DP;Kozak I
目的是介绍沙特阿拉伯新生血管性青光眼(NVG)的发病率和决定因素。对2002-2012年的NVG病例进行了回顾性回顾，以估计发病率。决定因素包括性别、年龄、合并症、晶状体状态、NVG类型和呈现时的视力。研究抗血管生成治疗对NVG发生率的影响。我们对597只眼的NVG进行了研究。发病率为6.6/万。这一比例从2008年的万分之13下降到了2012年的万分之0.1(P<；0.001)。2008年的下降恰逢沙特阿拉伯引入玻璃体内注射贝伐单抗。男性患NVG的风险明显更高(优势比[OR]=2.2)。糖尿病和高血压分别为88%和42.7%的患者合并NVG。在377名(72%)糖尿病患者中，血糖控制较差(HbA1C和GT；7%)。视力20/20~20/40者14眼(2%)，20/50~20/200者79眼(13%)，20/200~20/400者456眼(76%)，20/400者45眼(7%)。438只眼(73%)眼压>30 mm Hg。86只眼(14%)的杯盘比为>；0.8。术后早期(2002年~2007年)和晚期(2008年~2012年)CD比值(χ2=4，P=0.0 9)和前房角(P=0.8)无明显差异。对侧眼NVG的出现无明显差异(OR=0.8，P=0.3)。在非常大比例的患者中，NVG与糖尿病有关。它与男性显著相关，并与血糖控制差和表现时视力差有关。玻璃体内注射贝伐单抗后，NVG的发生率下降。
The aim is to present the incidence and determinants of neovascular glaucoma (NVG) in Saudi Arabia. A retrospective review of NVG cases (2002–2012) was included to estimate the incidence. The determinants included gender, age, comorbidities, lens status, type of NVG, and visual acuity on presentation. The impact of antiangiogenic therapy on NVG incidence was studied. We studied 597 eyes with NVG. The incidence was 6.6/10,000. It declined from 13/10,000 in 2008–0.1/10,000 in 2012 (P < 0.001). The decline in 2008 coincided with the introduction of intravitreal injection bevacizumab in Saudi Arabia. Males had a significantly higher NVG risk (odds ratio [OR] = 2.2). Diabetes and hypertension were associated with NVG in 88% and 42.7% of cases, respectively. In 377 (72%) diabetic patients, the glycemic control was poor (HbA1C >7%). Visual acuity was 20/20–20/40 in 14 (2%), 20/50–20/200 in 79 (13%), 20/200–20/400 in 456 (76%), and <20/400 in 45 (7%) eyes. Intraocular pressure was higher than 30 mmHg in 438 (73%) eyes. The cup-to-disc (CD) ratio was >0.8 in 86 (14%) eyes. During the early period (2002–2007) and later period (2008–2012), CD ratio (χ2 = 4, P = 0.09) and anterior chamber angle (P = 0.8) were not different. The presence of NVG in contralateral eye (OR = 0.8, P = 0.3) in both periods was similar. NVG was associated with diabetes in a very large proportion of patients. It was significantly associated with males, and with poor glycemic control and poor vision at presentation. The incidence of NVG declined after the introduction of intravitreal bevacizumab.