Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning
Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning
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DOI：
10.1038/ncb1820
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发表时间：
2009-01-01
影响因子：
21.3
通讯作者：
Nishida, Eisuke
中科院分区：
文献类型：
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作者：
Hanafusa, Hiroshi;Matsumoto, Kunihiro;Nishida, Eisuke
ERK激活的不同模式，持续或短暂，是培养细胞中细胞命运决定所必需的。在这里，我们表明，非洲爪蟾Sprouty2（XSpry2）控制ERK活性的持续时间，从而有助于建立中胚层形成过程中的背腹图案。此外，非洲爪蟾Fos（XFos）可以作为非洲爪蟾胚胎中ERK信号传导持续时间的分子传感器。这项工作提供了第一个证据，即调节ERK活性的持续时间有助于在整个生物体中决定细胞命运。
Distinct modes of ERK activation, sustained or transient, are essential for cell fate decision in cultured cells. Here we show that Xenopus laevis Sprouty2 (XSpry2) controls the duration of ERK activity and thereby contributes to the establishment of dorsoventral patterning during mesoderm formation. furthermore, Xenopus Fos (XFos) can function as a molecular sensor of the ERK signalling duration in Xenopus embryos. this work provides the first evidence that regulating the duration of ERK activity contributes to cell fate decisions in the context of the whole organism.