Development of radioligands for the dopamine transporter
Development of radioligands for the dopamine transporter
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DOI：
10.1007/bf02040050
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发表时间：
1996-05
影响因子：
1.6
通讯作者：
L. Müller;C. Halldin;C. Lundkvist;C. Swahn;C. Foged;H. Hall;P. Karlsson;N. Ginovart;Y. Nakashima;T. Suhara;L. Farde
中科院分区：
文献类型：
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作者：
L. Müller;C. Halldin;C. Lundkvist;C. Swahn;C. Foged;H. Hall;P. Karlsson;N. Ginovart;Y. Nakashima;T. Suhara;L. Farde
级别：文件。Dr.DegreeYear:1994年学院：卡罗林斯卡研究所（瑞典）多巴胺转运蛋白是一种定位于突触前多巴胺神经元的蛋白质，被认为是帕金森病和阿尔茨海默病等退行性脑部疾病的标志物。其目的是开发新的放射性配体，用于通过正电子发射断层扫描检查活体人脑中的多巴胺转运蛋白。化合物属于两个不同的化学类别，二苯甲基取代的哌嗪衍生物和3-取代的可卡因类似物用不同的放射性核素进行放射性标记。本文用寿命较长的放射性核素H、Br和I标记放射性配体进行体外脑组织匀浆研究，用C、F和Br标记放射性配体进行体外放射自显影研究和猴和人的体内PET研究。
Degree: Fil. Dr.DegreeYear: 1994Institute: Karolinska Institutet (Sweden)The dopamine transporter, a protein localized to the presynaptic dopamine neuron, has been suggested as a marker for degenerative brain disorders such as Parkinson''s and Alzheimer''s disease. The aim was to develop new radioligands for the examination of the dopamine transporter in the living human brain by positron emission tomography. Compounds belonging to two different chemical classes, the benzhydryl substituted piperazine derivatives and 3-substituted analogues of cocaine were radiolabelled with different radionuclides. The comparatively long lived radionuclidesH,Br andI were used to label radioligands for studies on brain homogenates in vitro.C,F andBr were used for autoradiographic studies in vitro or for PET studies in vivo on monkey and humans.