Impact of rTMS on functional connectivity within the language network in schizophrenia patients with auditory hallucinations
Impact of rTMS on functional connectivity within the language network in schizophrenia patients with auditory hallucinations
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DOI：
10.1016/j.schres.2017.01.049
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发表时间：
2017-11-01
影响因子：
4.5
通讯作者：
Dollfus, S.
中科院分区：
文献类型：
--
作者：
Briend, F.;Leroux, E.;Dollfus, S.
本研究探讨了精神分裂症患者（SZ）言语幻听（AVH）语言网络的功能连接（FC）以及rTMS的治疗效果。SZ在第一次fMRI会话后接受20 Hz rTMS。与HC相比，SZ在语言网络中表现出减少的FC。虽然AVH在12天后有所改善，但未观察到FC的变化。这表明高频rTMS对AVH的有效性，而rTMS对语言网络中的FC没有任何影响。(C)2017爱思唯尔B.V.保留所有权利。
This exploratory study investigated the functional connectivity (FC) in the language network in schizophrenia patients (SZ) with auditory verbal hallucinations (AVHs), and the therapeutic efficacy of rTMS on it. Eleven SZ with AVHs and 10 healthy controls (HC) underwent two fMRI sessions using a speech listening paradigm. SZ received 20 Hz rTMS following the first fMRI session. Compared to HC, SZ showed a reduced FC in the language network. While AVHs improved after 12 days, no changes in FC were observed. This suggests the efficacy of high-frequency rTMS on AVH without any impact for rTMS on FC within the language network. (C) 2017 Elsevier B.V. All rights reserved.