Antisense oligonucleotide is a promising intervention for liver diseases.
Antisense oligonucleotide is a promising intervention for liver diseases.
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反义寡核苷酸是一种有前景的肝病干预方法
DOI：
10.3389/fphar.2022.1061842
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发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
肝脏作为机体重要的代谢器官，在维持机体正常稳态中起着至关重要的作用。然而，随着人们生活水平的提高和不健康生活方式的增多，肝脏负担过重。这使得肝病成为世界范围内导致死亡的主要原因之一。在不良因素的影响下，肝病可由单纯脂肪变性发展为肝炎、肝纤维化，最后发展为肝硬化和肝癌，死亡率随之升高。到目前为止，还没有公认的有效治疗肝病的方法。根据目前的研究，反义寡核苷酸（ASO）作为肝脏疾病的替代干预手段，具有高效、低毒、低剂量、特异性强、附加阳性等特点，有望成为一种有效的治疗手段。本文将首先介绍ASO的设计、改良、传递和作用机制，然后总结ASO在肝脏疾病治疗中的应用，包括非酒精性脂肪性肝病（NAFLD）、肝炎、肝纤维化和肝癌。最后，我们讨论了ASO药物转移到临床应用的挑战和观点。本文综述了ASO在肝脏疾病治疗中的综合系统功能。
As the body’s critical metabolic organ, the liver plays an essential role in maintaining proper body homeostasis. However, as people’s living standards have improved and the number of unhealthy lifestyles has increased, the liver has become overburdened. These have made liver disease one of the leading causes of death worldwide. Under the influence of adverse factors, liver disease progresses from simple steatosis to hepatitis, to liver fibrosis, and finally to cirrhosis and cancer, followed by increased mortality. Until now, there has been a lack of accepted effective treatments for liver disease. Based on current research, antisense oligonucleotide (ASO), as an alternative intervention for liver diseases, is expected to be an effective treatment due to its high efficiency, low toxicity, low dosage, strong specificity, and additional positive characteristics. In this review, we will first introduce the design, modification, delivery, and the mechanisms of ASO, and then summarize the application of ASO in liver disease treatment, including in non-alcoholic fatty liver disease (NAFLD), hepatitis, liver fibrosis, and liver cancer. Finally, we discuss challenges and perspectives on the transfer of ASO drugs into clinical use. This review provides a current and comprehensive understanding of the integrative and systematic functions of ASO for its use in liver disease.
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影响因子：
7.3
作者：
Brown, Dean G.;Wobst, Heike J.
通讯作者：
Wobst, Heike J.
影响因子：
5.6
作者：
Andronescu, M;Zhang, ZC;Condon, A
通讯作者：
Condon, A
影响因子：
4.8
作者：
Cansby, Emmelie;Kulkarni, Nagaraj M.;Mahlapuu, Margit
通讯作者：
Mahlapuu, Margit
影响因子：
4.8
作者：
Caputo, Mara;Kurhe, Yeshwant;Mahlapuu, Margit
通讯作者：
Mahlapuu, Margit
DOI：
10.1016/j.jcmgh.2018.12.004
发表时间：
2019-01-01
影响因子：
7.2
作者：
Cansby, Emmelie;Nunez-Duran, Esther;Mahlapuu, Margit
通讯作者：
Mahlapuu, Margit