Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss
Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss
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DOI：
10.1016/j.bbrc.2004.09.186
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发表时间：
2004-11-26
影响因子：
3.1
通讯作者：
Kominami, R
中科院分区：
文献类型：
--
作者：
Nemoto, M;Morita, Y;Kominami, R
人类的遗传变异可能在确定年龄相关性听力损失（阿勒）的个体易感性范围中发挥作用，但由于解剖人类复杂特征的困难，尚未确定任何贡献基因座。本文报道了一组C57 BL/6 J（136）和NISM品系的同源小鼠阿勒基因座的定位，该基因座覆盖了一半以上的染色体组。136品系从10月龄开始表现出阿勒，而来自日本野生小鼠的MSM品系在整个生命中具有正常的听力。在不同月龄时对小组中的个体进行听觉脑干反应（ABR）检查，揭示了一种特定的菌株（136-Chr 17（MSM））用MSM衍生的染色体取代17号染色体，显示出显著的抗性，在18个月龄时仍然具有良好的听力。随后使用B6-Chr 17（MSM）和136之间的杂交中的89个个体进行了定位，结果显示ABR阈值与D17 Mit 119附近的位点显著相关。这些结果显示在染色体17上的新的AHL抗性基因座，命名为Ahl 3。(C)2004年爱思唯尔公司All rights reserved.
Genetic variation in humans probably plays a role in determining the range of individual susceptibility to age-related hearing loss (AHL), but no contributing loci have been identified because of the difficulties of dissecting complex traits in humans. This paper reports mapping of an AHL locus using a panel of consomic mice between C57BL/6J (136) and NISM strains, which covered more than a half of chromosome sets. 136 strain exhibited AHL beginning at 10 months of age whereas MSM strain, derived from Japanese wild mice, had normal hearing throughout life. Individuals in the panel were examined with auditory brainstem response (ABR) at various months of age, revealing that one particular strain (136-Chr17(MSM)) substituting the chromosome 17 with the MSM-derived one showed a prominent resistance, having still good hearing at 18 months of age. Subsequent mapping using 89 individuals in the cross between B6-Chr17(MSM) and 136 was performed, which showed a significant association of ABR thresholds with loci in the vicinity of D17Mit119. These results show a novel AHL-resistant locus, designated as Ahl3, on the chromosome 17. (C) 2004 Elsevier Inc. All rights reserved.