Application of 3D NMR for Structure Determination of Peptide Natural Products.
Application of 3D NMR for Structure Determination of Peptide Natural Products.
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DOI：
10.1021/acs.joc.5b01486
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发表时间：
2015-09-04
期刊：
影响因子：
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通讯作者：
Bugni TS
中科院分区：
文献类型：
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作者：
Zhang F;Adnani N;Vazquez-Rivera E;Braun DR;Tonelli M;Andes DR;Bugni TS
尽管核磁共振技术取得了很大的进步，但结构测定的速度往往很慢，成为天然产物发现的瓶颈。消除这一瓶颈将大大提高抗生素发现以及其他治疗领域的通量。总的来说，用于结构测定的更快的结构方法将以广泛的方式服务于天然产物社区。本报告介绍了三维核磁共振的第一个应用程序，阐明两个微生物产生的肽天然产物与新的结构。该方法具有成本效益，并大大提高了对拟议结构的信心。
Despite the advances in NMR, structure determination is often slow and constitutes a bottleneck in natural products discovery. Removal of this bottleneck would greatly improve the throughput for antibiotic discovery as well as other therapeutic areas. Overall, faster structure methods for structure determination will serve the natural products community in a broad manner. This report describes the first application of 3D NMR for elucidation of two microbially produced peptide natural products with novel structures. The methods are cost-effective and greatly improve the confidence in a proposed structure.