Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo
Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo
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DOI：
10.1117/1.3333545
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发表时间：
2010-03-01
影响因子：
3.5
通讯作者：
Wang, Lihong V.
中科院分区：
文献类型：
--
作者：
Song, Liang;Maslov, Konstantin;Wang, Lihong V.
通过基于超声阵列的精细实时光声显微镜（UA-PAM）系统，我们证明了人体脉动动力学无创体内成像的可行性。该系统能够以 50 Hz 的频率进行实时 B 扫描成像和高速 3D 成像，并通过对大鼠和人类的皮下微血管系统成像进行验证。验证后，对手掌手腕区域周围的人体动脉进行成像，并通过 20 毫秒 B 扫描成像时间分辨率监测其脉动动态，包括动脉脉动运动和血红蛋白浓度变化。据我们所知，这是人类生理动力学实时光声成像的首次演示。我们的结果表明，UA-PAM 可以为临床前和临床成像环境中的功能和生理动力学研究提供许多新的可能性。 (C) 2010 年光电仪器工程师协会。 [DOI：10.1117/1.3333545]
With a refined ultrasound-array-based real-time photoacoustic microscopy (UA-PAM) system, we demonstrate the feasibility of noninvasive in vivo imaging of human pulsatile dynamics. The system, capable of real-time B-scan imaging at 50 Hz and high-speed 3-D imaging, is validated by imaging the subcutaneous microvasculature in rats and humans. After the validation, a human artery around the palm-wrist area is imaged, and its pulsatile dynamics, including the arterial pulsatile motion and changes in hemoglobin concentration, is monitored with 20-ms B-scan imaging temporal resolution. To our knowledge, this is the first demonstration of real-time photoacoustic imaging of human physiological dynamics. Our results show that UA-PAM can potentially enable many new possibilities for studying functional and physiological dynamics in both preclinical and clinical imaging settings. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3333545]