'Sputnik': a programmatic approach to improve tuberculosis treatment adherence and outcome among defaulters
'Sputnik': a programmatic approach to improve tuberculosis treatment adherence and outcome among defaulters
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DOI：
10.5588/ijtld.10.0531
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发表时间：
2011-10-01
影响因子：
4
通讯作者：
Keshavjee, S.
中科院分区：
文献类型：
--
作者：
Gelmanova, I. Y.;Taran, D. V.;Keshavjee, S.
环境：在俄罗斯联邦的托木斯克市，一种新的以患者为中心的结核病（TB）治疗方案“Sputnik”被引入到高风险的患者中，目的：评估Sputnik干预对患者违约率的影响。设计：我们分析了参与该项目的患者的特征，斯普特尼克项目参与者在干预前和干预期间的治疗依从性，结果：对于转介到该计划后继续其现有方案的患者（n = 46），平均依从性治疗增加了56%（从52%的处方剂量前登记到81%）。对于转诊后开始新治疗方案的患者（n = 5），平均依从性为83%。耐多药结核病（MDR-TB; n = 38）患者的平均依从性为79%，所有其他患者（n = 13）的平均依从性为89%。治愈率为71.1%的耐多药结核病患者，60%的所有其他人和68%的程序overall.CONCLUSION：人造卫星的干预是成功的，在高风险的非依从性患者的治疗违约率降低。
SETTING: A novel patient-centered tuberculosis (TB) treatment delivery program, 'Sputnik', was introduced for patients at high risk of treatment default in Tomsk City, Russian Federation.OBJECTIVE: To assess the effects of the Sputnik intervention on patient default rates.DESIGN: We analyzed the characteristics of patients referred to the program, treatment adherence of Sputnik program enrollees before and during the intervention, and final outcomes for all patients referred to the Sputnik program.RESULTS: For patients continuing their existing regimens after referral to the program (n = 46), mean adherence to treatment increased by 56% (from 52% of prescribed doses prior to enrolment to 81%). For patients initiating new regimens after referral (n = 5), mean adherence was 83%. Mean adherence for patients with multidrug-resistant TB (MDR-TB; n = 38) was 79% and for all others (n = 13) it was 89%. The cure rate was 71.1% for patients with MDR-TB, 60% for all others and 68% in the program overall.CONCLUSION: The Sputnik intervention was successful in reducing rates of treatment default among patients at high risk for non-adherence.