Increasing pulse wave velocity in a realistic cardiovascular model does not increase pulse pressure with age.
Increasing pulse wave velocity in a realistic cardiovascular model does not increase pulse pressure with age.
复制标题
在现实心血管模型中增加脉搏波速度不会随着年龄的增长而增加脉压。
DOI：
10.1152/ajpheart.00801.2011
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Quick,ChristopherM
中科院分区：
文献类型：
--
作者：
Mohiuddin,MohammadW;Rihani,RyanJ;Laine,GlenA;Quick,ChristopherM
The mechanism of the well-documented increase in aortic pulse pressure (PP) with age is disputed. Investigators assuming a classical windkessel model believe that increases in PP arise from decreases in total arterial compliance (Ctot) and increases in total peripheral resistance (Rtot) with age. Investigators assuming a more sophisticated pulse transmission model believe PP rises because increases in pulse wave velocity (cph) make the reflected pressure wave arrive earlier, augmenting systolic pressure. It has recently been shown, however, that increases incphdo not have a commensurate effect on the timing of the reflected wave. We therefore used a validated, large-scale, human arterial system model that includes realistic pulse wave transmission to determine whether increases incphcause increased PP with age. First, we made the realistic arterial system model age dependent by altering cardiac output (CO),Rtot,Ctot, andcphto mimic the reported changes in these parameters from age 30 to 70. Then,cphwas theoretically maintained constant, whileCtot,Rtot, and CO were altered. The predicted increase in PP with age was similar to the observed increase in PP. In a complementary approach,Ctot,Rtot, and CO were theoretically maintained constant, andcphwas increased. The predicted increase in PP was negligible. We found that increases incphhave a limited effect on the timing of the reflected wave but cause the system to degenerate into a windkessel. Changes in PP can therefore be attributed to a decrease inCtot.
