Obesity Impairs the Action of the Neuroendocrine Ghrelin System.
Obesity Impairs the Action of the Neuroendocrine Ghrelin System.
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DOI：
10.1016/j.tem.2015.09.010
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Andrews ZB
中科院分区：
文献类型：
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作者：
Zigman JM;Bouret SG;Andrews ZB
Ghrelin是一种代谢荷尔蒙，通过调节食欲和能量消耗来促进能量节约。尽管一些研究表明，在高热量饮食中，拮抗Ghrelin功能可以减轻体重增加和葡萄糖耐量，但关于Ghrelin在肥胖状态下的代谢作用的信息很少。在这篇综述中，我们讨论了肥胖诱导的中枢Ghrelin抵抗在调节行为的神经回路中的新概念，以及胃Ghrelin分泌的损害。有趣的是，减肥恢复了胃促生长素的分泌和功能，我们假设，胃促生长素抵抗是一种旨在保护在食物供应时期建立的较高体重设定点的机制，以在食物短缺的时期最大限度地增加能量储备。
Ghrelin is a metabolic hormone that promotes energy conservation by regulating appetite and energy expenditure. Although some studies suggest that antagonizing ghrelin function attenuates body weight gain and glucose intolerance on a high calorie diet, there is little information about the metabolic actions of ghrelin in the obese state. In this review, we discuss the novel concept of obesity-induced central ghrelin resistance in neural circuits regulating behavior, and impaired ghrelin secretion from the stomach. Interestingly, weight loss restores ghrelin secretion and function, and we hypothesize that ghrelin resistance is a mechanism designed to protect a higher body weight set-point established during times of food availability, to maximize energy reserves during a time of food scarcity.