Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace
Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace
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DOI：
10.1016/s0925-4773(00)00414-7
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发表时间：
2000-10-01
影响因子：
2.6
通讯作者：
Bober, E
中科院分区：
文献类型：
--
作者：
Adamska, M;Léger, S;Bober, E
小鼠同源框基因 Nkx5-1 的直系同源物在斑马鱼中被克隆并进行了表征。与小鼠和雏鸡一样，斑马鱼 Nkx5-1 基因在耳基板和囊泡以及形成前庭声神经节的细胞中表达。此外，斑马鱼中出现了一个新的表达域，即侧线，支持这两个器官的共同前体假设。在 FGF8 斑马鱼突变体 ace 中，耳结构中 Nkx5-1 的表达减弱。在前庭听神经节细胞中观察到 zfNkx5-1 表达最显着的降低。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
An orthologue of the mouse homeobox gene Nkx5-1 was cloned and characterized in the zebrafish. As in the mouse and chick, the zebrafish Nkx5-1 gene is expressed in the ear placode and vesicle and in cells forming the vestibule-acoustic ganglion. In addition, a novel expression domain, the lateral line, appears in the zebrafish, supporting a common precursor hypothesis for these two organs. In the FGF8 zebrafish mutant ace, expression of Nkx5-1 in the otic structures is diminished. The most significant reduction of zfNkx5-1 expression was observed in cells of the vestibule-acoustic ganglion. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.