Platelet membrane glycoproteins in normal dogs and dogs with hemostatic defects.
Platelet membrane glycoproteins in normal dogs and dogs with hemostatic defects.
复制标题
正常犬和有止血缺陷的犬的血小板膜糖蛋白。
DOI：
10.2460/javma.1990.197.10.1342
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
Dodds Wj
中科院分区：
文献类型：
--
作者：
Raymond Sl;Dodds Wj
采用SDS-PAGE对TT或VWD犬和正常对照的血小板富膜部分溶解的糖蛋白进行比较。结果与类似的人类疾病相似。正常和VWD犬血小板MPs都含有三种主要的糖蛋白和四种较小分子量的蛋白，用PAS试剂染色为碳水化合物。相比之下，TT犬的MPs中GP I浓度较高，GP II表达不同，GP III浓度较低。这些发现再次强调了这些人类止血缺陷模型的比较研究的价值。
: Glycoproteins solubilized from membrane-enriched fractions of platelets from dogs with TT or VWD and from normal controls were compared by SDS-PAGE. The results were similar to those for the analogous human disorders. Both normal and VWD canine platelet MPs contained three major glycoproteins as well as four smaller-molecular-weight proteins that stained for carbohydrate with the PAS reagent. In contrast, MPs from dogs with TT had a higher concentration of GP I, a varied expression of GP II, and a lower concentration of GP III. The findings re-emphasize the value of comparative studies of these models of human hemostatic defects.